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New-onset Obesity After Lung Transplantation: Incidence, Risk Factors, and Clinical Outcomes.
Jomphe, Valérie; Bélanger, Noémie; Beauchamp-Parent, Caroline; Poirier, Charles; Nasir, Basil S; Ferraro, Pasquale; Lands, Larry C; Mailhot, Geneviève.
Affiliation
  • Jomphe V; Lung Transplant Program, Centre Hospitalier de l'Université de Montréal, Montreal, QC, Canada.
  • Bélanger N; Department of Nutrition, Faculty of Medicine, Université de Montreal, Montreal, QC, Canada.
  • Beauchamp-Parent C; Department of Nutrition, Faculty of Medicine, Université de Montreal, Montreal, QC, Canada.
  • Poirier C; Lung Transplant Program, Centre Hospitalier de l'Université de Montréal, Montreal, QC, Canada.
  • Nasir BS; Department of Medicine, Centre Hospitalier de l'Université de Montréal, Montreal, QC, Canada.
  • Ferraro P; Lung Transplant Program, Centre Hospitalier de l'Université de Montréal, Montreal, QC, Canada.
  • Lands LC; Division of Thoracic Surgery, Department of Surgery, Centre Hospitalier de l'Université de Montréal, Montreal, QC, Canada.
  • Mailhot G; Lung Transplant Program, Centre Hospitalier de l'Université de Montréal, Montreal, QC, Canada.
Transplantation ; 106(11): 2247-2255, 2022 11 01.
Article in En | MEDLINE | ID: mdl-35749757
BACKGROUND: Lung transplant (LTx) recipients who gain weight after transplantation may experience an upward shift in body mass index (BMI) that places them in the obese category. The incidence, risk factors, and impact on metabolic health and mortality of new-onset obesity have not been documented in the LTx setting. METHODS: This single-center retrospective study included 564 LTx recipients. Individuals were stratified according to their BMI trajectories from pretransplant evaluation up to 10 y posttransplant. New-onset obesity was defined as a pretransplant BMI <30 kg/m 2 and posttransplant BMI >30 kg/m 2 . The incidence, risk factors, and posttransplant diabetes mellitus, metabolic syndrome, and mortality of recipients with new-onset obesity were compared with those of nonobese (BMI <30 kg/m 2 , pre/post-LTx), consistently obese (BMI >30 kg/m 2 , pre/post-LTx), and obese recipients with weight loss (BMI >30 kg/m 2 pre-LTx, BMI <30 kg/m 2 post-LTx). RESULTS: We found that 14% of recipients developed obesity after transplantation. Overweight individuals (odds ratio [OR]: 9.01; 95% confidence interval [CI] [4.86-16.69]; P < 0.001) and candidates with chronic obstructive pulmonary disease (OR: 6.93; 95% CI [2.30-20.85]; P = 0.001) and other diagnoses (OR: 4.28; 95% CI [1.22-14.98]; P = 0.023) were at greater risk. Multivariable regression analysis showed that new-onset obesity was associated with a greater risk of metabolic syndrome (hazard ratio: 1.70; 95% CI [1.17-2.46]; P = 0.005), but not of posttransplant diabetes mellitus, than nonobesity. Recipients with new-onset obesity had a survival comparable to that of consistently obese individuals. CONCLUSIONS: A greater understanding of the multifaceted nature of post-LTx obesity may lead to interventions that are better tailored to the characteristics of these individuals.
Subject(s)

Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Lung Transplantation / Metabolic Syndrome / Diabetes Mellitus Type of study: Diagnostic_studies / Etiology_studies / Incidence_studies / Observational_studies / Prognostic_studies / Risk_factors_studies Limits: Humans Language: En Journal: Transplantation Year: 2022 Document type: Article Affiliation country: Canada Country of publication: United States

Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Lung Transplantation / Metabolic Syndrome / Diabetes Mellitus Type of study: Diagnostic_studies / Etiology_studies / Incidence_studies / Observational_studies / Prognostic_studies / Risk_factors_studies Limits: Humans Language: En Journal: Transplantation Year: 2022 Document type: Article Affiliation country: Canada Country of publication: United States