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Imipramine and olanzapine block apoE4-catalyzed polymerization of Aß and show evidence of improving Alzheimer's disease cognition.
Johnson, Noah R; Wang, Athena C-J; Coughlan, Christina; Sillau, Stefan; Lucero, Esteban; Viltz, Lisa; Markham, Neil; Allen, Cody; Dhanasekaran, A Ranjitha; Chial, Heidi J; Potter, Huntington.
Affiliation
  • Johnson NR; Department of Neurology, University of Colorado Alzheimer's and Cognition Center, Linda Crnic Institute for Down Syndrome, University of Colorado, Anschutz Medical Campus, Aurora, CO, USA.
  • Wang AC; Department of Neurology, University of Colorado Alzheimer's and Cognition Center, Linda Crnic Institute for Down Syndrome, University of Colorado, Anschutz Medical Campus, Aurora, CO, USA.
  • Coughlan C; Department of Neurology, University of Colorado Alzheimer's and Cognition Center, Linda Crnic Institute for Down Syndrome, University of Colorado, Anschutz Medical Campus, Aurora, CO, USA.
  • Sillau S; Department of Neurology, University of Colorado Alzheimer's and Cognition Center, Linda Crnic Institute for Down Syndrome, University of Colorado, Anschutz Medical Campus, Aurora, CO, USA.
  • Lucero E; Department of Neurology, University of Colorado Alzheimer's and Cognition Center, Linda Crnic Institute for Down Syndrome, University of Colorado, Anschutz Medical Campus, Aurora, CO, USA.
  • Viltz L; Department of Neurology, University of Colorado Alzheimer's and Cognition Center, Linda Crnic Institute for Down Syndrome, University of Colorado, Anschutz Medical Campus, Aurora, CO, USA.
  • Markham N; Department of Neurology, University of Colorado Alzheimer's and Cognition Center, Linda Crnic Institute for Down Syndrome, University of Colorado, Anschutz Medical Campus, Aurora, CO, USA.
  • Allen C; Department of Neurology, University of Colorado Alzheimer's and Cognition Center, Linda Crnic Institute for Down Syndrome, University of Colorado, Anschutz Medical Campus, Aurora, CO, USA.
  • Dhanasekaran AR; Department of Neurology, University of Colorado Alzheimer's and Cognition Center, Linda Crnic Institute for Down Syndrome, University of Colorado, Anschutz Medical Campus, Aurora, CO, USA.
  • Chial HJ; Department of Neurology, University of Colorado Alzheimer's and Cognition Center, Linda Crnic Institute for Down Syndrome, University of Colorado, Anschutz Medical Campus, Aurora, CO, USA.
  • Potter H; Department of Neurology, University of Colorado Alzheimer's and Cognition Center, Linda Crnic Institute for Down Syndrome, University of Colorado, Anschutz Medical Campus, Aurora, CO, USA. huntington.potter@cuanschutz.edu.
Alzheimers Res Ther ; 14(1): 88, 2022 06 29.
Article in En | MEDLINE | ID: mdl-35768831
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Apolipoprotein E4 / Alzheimer Disease Type of study: Observational_studies / Prognostic_studies / Risk_factors_studies Limits: Humans Language: En Journal: Alzheimers Res Ther Year: 2022 Document type: Article Affiliation country: United States Country of publication: United kingdom
Fulltext
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Apolipoprotein E4 / Alzheimer Disease Type of study: Observational_studies / Prognostic_studies / Risk_factors_studies Limits: Humans Language: En Journal: Alzheimers Res Ther Year: 2022 Document type: Article Affiliation country: United States Country of publication: United kingdom