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Design and synthesis of chromone-based monoamine oxidase B inhibitors with improved drug-like properties.
Reis, Joana; Fernandes, Carlos; Salem, Hoda; Maia, Marta; Tomé, Cláudia; Benfeito, Sofia; Teixeira, José; Oliveira, Paulo J; Uriarte, Eugenio; Ortuso, Francesco; Alcaro, Stefano; Bagetta, Donatella; Cagide, Fernando; Borges, Fernanda.
Affiliation
  • Reis J; CIQUP-IMS/Department of Chemistry and Biochemistry, Faculty of Sciences, University of Porto, 4169-007, Porto, Portugal.
  • Fernandes C; CIQUP-IMS/Department of Chemistry and Biochemistry, Faculty of Sciences, University of Porto, 4169-007, Porto, Portugal.
  • Salem H; CIQUP-IMS/Department of Chemistry and Biochemistry, Faculty of Sciences, University of Porto, 4169-007, Porto, Portugal.
  • Maia M; CIQUP-IMS/Department of Chemistry and Biochemistry, Faculty of Sciences, University of Porto, 4169-007, Porto, Portugal.
  • Tomé C; CIQUP-IMS/Department of Chemistry and Biochemistry, Faculty of Sciences, University of Porto, 4169-007, Porto, Portugal.
  • Benfeito S; CIQUP-IMS/Department of Chemistry and Biochemistry, Faculty of Sciences, University of Porto, 4169-007, Porto, Portugal.
  • Teixeira J; CIQUP-IMS/Department of Chemistry and Biochemistry, Faculty of Sciences, University of Porto, 4169-007, Porto, Portugal; CNC - Center for Neuroscience and Cell Biology, UC-Biotech Building, Biocant Park, University of Coimbra, Cantanhede, 3060-197, Portugal.
  • Oliveira PJ; CNC - Center for Neuroscience and Cell Biology, UC-Biotech Building, Biocant Park, University of Coimbra, Cantanhede, 3060-197, Portugal.
  • Uriarte E; Department of Organic Chemistry, Faculty of Pharmacy, Universidad of Santiago de Compostela, 15782, Santiago de Compostela, Spain; Applied Chemical Science Institute, Universidad Autonoma de Chile, 7500912, Santiago de Chile, Chile.
  • Ortuso F; Dipartimento di Scienze della Salute, Università Magna Græcia di Catanzaro, Campus "Salvatore Venuta", Viale Europa, 88100, Catanzaro, Italy; Net4Science srl, academic spinoff, Università Magna Græcia di Catanzaro, Campus" Salvatore Venuta", Viale Europa, 88100, Catanzaro, Italy.
  • Alcaro S; Dipartimento di Scienze della Salute, Università Magna Græcia di Catanzaro, Campus "Salvatore Venuta", Viale Europa, 88100, Catanzaro, Italy; Net4Science srl, academic spinoff, Università Magna Græcia di Catanzaro, Campus" Salvatore Venuta", Viale Europa, 88100, Catanzaro, Italy.
  • Bagetta D; Net4Science srl, academic spinoff, Università Magna Græcia di Catanzaro, Campus" Salvatore Venuta", Viale Europa, 88100, Catanzaro, Italy.
  • Cagide F; CIQUP-IMS/Department of Chemistry and Biochemistry, Faculty of Sciences, University of Porto, 4169-007, Porto, Portugal. Electronic address: fernando.fagin@fc.up.pt.
  • Borges F; CIQUP-IMS/Department of Chemistry and Biochemistry, Faculty of Sciences, University of Porto, 4169-007, Porto, Portugal. Electronic address: fborges@fc.up.pt.
Eur J Med Chem ; 239: 114507, 2022 Sep 05.
Article in En | MEDLINE | ID: mdl-35772321
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Chromones / Monoamine Oxidase Inhibitors Limits: Humans Language: En Journal: Eur J Med Chem Year: 2022 Document type: Article Affiliation country: Portugal Country of publication: France
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Chromones / Monoamine Oxidase Inhibitors Limits: Humans Language: En Journal: Eur J Med Chem Year: 2022 Document type: Article Affiliation country: Portugal Country of publication: France