Correlation between age, location, orientation, loading velocity and delamination strength in the human aorta.

ABSTRACT

Aortic dissection is a biomechanical phenomenon associated with a failure of internal cohesion, which manifests itself through the delamination of the aortic wall. The goal of this study is to deepen our knowledge of the delamination strength of the aorta. To achieve this, 661 peeling experiments were carried out with strips of the human aorta collected from 46 cadavers. The samples were ordered into groups with respect to (1) anatomical location, (2) orientation of the sample, and (3) extension rate used within the experiment. The obtained results are in accordance with the hypothesis that delamination resistance is not sensitive to the extension rates 0.1, 1, 10, and 50 mms-1. We arrived at this conclusion for all positions along the aorta investigated in our study. These were the thoracic ascending (AAs), thoracic descending (ADs), and the abdominal aorta (AAb), simultaneously considering both the longitudinal (L) as well as the circumferential (C) orientations of the samples. On the other hand, our results showed that the delamination strength differs significantly with respect to the anatomical position and orientation of the sample. The medians of the delamination strength were as follows, 4.1 in AAs-L, 3.2 in AAs-C, 3.1 in ADs-L, 2.4 in ADs-C, AAb-L in 3.6, and 2.7 in AAb-C case (all values are in 0.01·Nmm-1). This suggests that resistance to crack propagation should be an anisotropic property and that the aorta is inhomogeneous along its length from the point of view of delamination resistance. Finally, correlation analysis proved that the delamination strength of the human aorta significantly decreases with age.