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Box-shaped ribozyme octamer formed by face-to-face dimerization of a pair of square-shaped ribozyme tetramers.
Islam, Md Dobirul; Hidaka, Kumi; Suzuki, Yuki; Sugiyama, Hiroshi; Endo, Masayuki; Matsumura, Shigeyoshi; Ikawa, Yoshiya.
Affiliation
  • Islam MD; Graduate School of Innovative Life Science, University of Toyama, 3190 Gofuku, Toyama 930-8555, Japan.
  • Hidaka K; Department of Chemistry, Graduate School of Science, Kyoto University, Kyoto 606-8502, Japan.
  • Suzuki Y; Department of Chemistry, Graduate School of Science, Kyoto University, Kyoto 606-8502, Japan; Division of Chemistry for Materials, Graduate School of Engineering, Mie University, Tsu 514-8507, Japan.
  • Sugiyama H; Department of Chemistry, Graduate School of Science, Kyoto University, Kyoto 606-8502, Japan; Institute for Integrated Cell-Material Sciences, Kyoto University, Kyoto 606-8502, Japan.
  • Endo M; Department of Chemistry, Graduate School of Science, Kyoto University, Kyoto 606-8502, Japan; Institute for Integrated Cell-Material Sciences, Kyoto University, Kyoto 606-8502, Japan; Organization for Research and Development of Innovative Science and Technology, Kansai University, Osaka 564-8680, J
  • Matsumura S; Graduate School of Innovative Life Science, University of Toyama, 3190 Gofuku, Toyama 930-8555, Japan; Department of Chemistry, Graduate School of Science and Engineering, University of Toyama, 3190 Gofuku, Toyama 930-8555, Japan.
  • Ikawa Y; Graduate School of Innovative Life Science, University of Toyama, 3190 Gofuku, Toyama 930-8555, Japan; Department of Chemistry, Graduate School of Science and Engineering, University of Toyama, 3190 Gofuku, Toyama 930-8555, Japan. Electronic address: yikawa@sci.u-toyama.ac.jp.
J Biosci Bioeng ; 134(3): 195-202, 2022 Sep.
Article in En | MEDLINE | ID: mdl-35810135
ABSTRACT
Naturally occurring ribozymes with defined three-dimensional (3D) structures serve as promising platforms for the design and construction of artificial RNA nanostructures. We constructed a hexameric ribozyme nanostructure by face-to-face dimerization of a pair of triangular ribozyme trimers, unit RNAs of which were derived from the Tetrahymena group I ribozyme. In this study, we have expanded the dimerization strategy to a square-shaped ribozyme tetramer by introducing four pillar units. The resulting box-shaped nanostructures, which contained eight ribozyme units, can be assembled from either four or two components of their unit RNAs.
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Tetrahymena / RNA, Catalytic Language: En Journal: J Biosci Bioeng Journal subject: ENGENHARIA BIOMEDICA / MICROBIOLOGIA Year: 2022 Document type: Article Affiliation country: Japan
Fulltext
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Tetrahymena / RNA, Catalytic Language: En Journal: J Biosci Bioeng Journal subject: ENGENHARIA BIOMEDICA / MICROBIOLOGIA Year: 2022 Document type: Article Affiliation country: Japan