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Specialized Proresolving Mediators Protect Against Experimental Autoimmune Myocarditis by Modulating Ca2+ Handling and NRF2 Activation.
Val-Blasco, Almudena; Prieto, Patricia; Jaén, Rafael Iñigo; Gil-Fernández, Marta; Pajares, Marta; Domenech, Nieves; Terrón, Verónica; Tamayo, María; Jorge, Inmaculada; Vázquez, Jesús; Bueno-Sen, Andrea; Vallejo-Cremades, María Teresa; Pombo-Otero, Jorge; Sanchez-García, Sergio; Ruiz-Hurtado, Gema; Gómez, Ana María; Zaragoza, Carlos; Crespo-Leiro, María Generosa; López-Collazo, Eduardo; Cuadrado, Antonio; Delgado, Carmen; Boscá, Lisardo; Fernández-Velasco, María.
Affiliation
  • Val-Blasco A; Innate Immune Response Group, La Paz University Hospital, Instituto de Investigación Biomédica del Hospital La Paz (IdiPAZ), Madrid, Spain.
  • Prieto P; Signaling and Cardiovascular Pathophysiology, Unite Mixte de Recherche S 1180, Institut National de la Santé et de la Recherche Médicale, Université Paris-Saclay, Paris, France.
  • Jaén RI; Pharmacology, Pharmacognosy, and Botany Department, Faculty of Pharmacy, Complutense University of Madrid, Madrid, Spain.
  • Gil-Fernández M; Centro de Investigación Biomédica en Red de Enfermedades Cardiovasculares (CIBERCV), Madrid, Spain.
  • Pajares M; Instituto de Investigaciones Biomédicas "Alberto Sols," Consejo Superior de Investigaciones Científicas, Autonomous University of Madrid (UAM), Madrid, Spain.
  • Domenech N; Innate Immune Response Group, La Paz University Hospital, Instituto de Investigación Biomédica del Hospital La Paz (IdiPAZ), Madrid, Spain.
  • Terrón V; Instituto de Investigaciones Biomédicas "Alberto Sols," Consejo Superior de Investigaciones Científicas, Autonomous University of Madrid (UAM), Madrid, Spain.
  • Tamayo M; Instituto de Investigaciones Biomédicas "Alberto Sols," Consejo Superior de Investigaciones Científicas, Autonomous University of Madrid (UAM), Madrid, Spain.
  • Jorge I; Centro de Investigación Biomédica en Red Sobre Enfermedades Neurodegenerativas, Madrid, Spain.
  • Vázquez J; Centro de Investigación Biomédica en Red de Enfermedades Cardiovasculares (CIBERCV), Madrid, Spain.
  • Bueno-Sen A; Instituto de Investigación Biomédica de A Coruña, Complexo Hospitalario Universitario de A Coruña, Sergas, Universidad da Coruña, A Coruña, Spain.
  • Vallejo-Cremades MT; Innate Immune Response Group, La Paz University Hospital, Instituto de Investigación Biomédica del Hospital La Paz (IdiPAZ), Madrid, Spain.
  • Pombo-Otero J; Instituto de Investigaciones Biomédicas "Alberto Sols," Consejo Superior de Investigaciones Científicas, Autonomous University of Madrid (UAM), Madrid, Spain.
  • Sanchez-García S; Centro de Investigación Biomédica en Red de Enfermedades Cardiovasculares (CIBERCV), Madrid, Spain.
  • Ruiz-Hurtado G; Centro Nacional de Investigaciones Cardiovasculares, Madrid, Spain.
  • Gómez AM; Centro de Investigación Biomédica en Red de Enfermedades Cardiovasculares (CIBERCV), Madrid, Spain.
  • Zaragoza C; Centro Nacional de Investigaciones Cardiovasculares, Madrid, Spain.
  • Crespo-Leiro MG; Innate Immune Response Group, La Paz University Hospital, Instituto de Investigación Biomédica del Hospital La Paz (IdiPAZ), Madrid, Spain.
  • López-Collazo E; Molecular Image and Immunohistochemistry Unit, IdiPAZ, La Paz University Hospital, Madrid, Spain.
  • Cuadrado A; Instituto de Investigación Biomédica de A Coruña, Complexo Hospitalario Universitario de A Coruña, Sergas, Universidad da Coruña, A Coruña, Spain.
  • Delgado C; Instituto de Investigaciones Biomédicas "Alberto Sols," Consejo Superior de Investigaciones Científicas, Autonomous University of Madrid (UAM), Madrid, Spain.
  • Boscá L; Centro de Investigación Biomédica en Red de Enfermedades Cardiovasculares (CIBERCV), Madrid, Spain.
  • Fernández-Velasco M; Cardiorenal Translational Laboratory, Institute of Research i+12, CIBERCV, Hospital Universitario 12 de Octubre, Madrid, Spain.
JACC Basic Transl Sci ; 7(6): 544-560, 2022 Jun.
Article in En | MEDLINE | ID: mdl-35818504
ABSTRACT
Specialized proresolving mediators and, in particular, 5(S), (6)R, 7-trihydroxyheptanoic acid methyl ester (BML-111) emerge as new therapeutic tools to prevent cardiac dysfunction and deleterious cardiac damage associated with myocarditis progression. The cardioprotective role of BML-111 is mainly caused by the prevention of increased oxidative stress and nuclear factor erythroid-derived 2-like 2 (NRF2) down-regulation induced by myocarditis. At the molecular level, BML-111 activates NRF2 signaling, which prevents sarcoplasmic reticulum-adenosine triphosphatase 2A down-regulation and Ca2+ mishandling, and attenuates the cardiac dysfunction and tissue damage induced by myocarditis.
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Full text: 1 Collection: 01-internacional Database: MEDLINE Language: En Journal: JACC Basic Transl Sci Year: 2022 Document type: Article Affiliation country: Spain
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Full text: 1 Collection: 01-internacional Database: MEDLINE Language: En Journal: JACC Basic Transl Sci Year: 2022 Document type: Article Affiliation country: Spain