Impact of hospital environmental cleaning with a potassium peroxymonosulphate-based environmental disinfectant and antimicrobial stewardship on the reduction of hospital-onset Clostridioides difficile infections.
J Hosp Infect
; 129: 181-188, 2022 Nov.
Article
in En
| MEDLINE
| ID: mdl-35820556
ABSTRACT
BACKGROUND:
A 1% potassium peroxymonosulphate-based environmental disinfectant (PPED) produces sodium hypochlorite when combined with sodium chloride, which functions as a disinfectant. However, little is known about the impact of hospital cleaning with PPED on hospital-onset Clostridioides difficile infection (HO-CDI).AIM:
To reduce HO-CDI, we promoted antimicrobial stewardship and hospital ward cleaning with PPED this study was conducted to evaluate their impact.METHODS:
We began a promotion of post-prescription review with feedback for broad-spectrum antimicrobials and hospital ward cleaning with PPED. We reviewed the ratio of HO-CDI, PPED consumption, and days of therapy (DOT) of broad-spectrum antimicrobials between July 2014 and March 2018, dividing this time into the pre-promotion (July 2014 to June 2015) and post-promotion periods (July 2015 to March 2018).FINDINGS:
Using interrupted time series analysis, an immediate significant change in HO-CDI was observed after intervention (P=0.03), although a downward trend was not observed over this period (P=0.19). Trends in PPED consumption significantly changed over this period (P=0.02). DOT of carbapenems decreased immediately after the intervention began (P<0.01). A Poisson regression analysis showed that PPED consumption and DOT of carbapenems were independent factors affecting HO-CDI (P=0.039 and 0.016, respectively).CONCLUSION:
We revealed that DOT of carbapenems and use of PPED were associated with the HO-CDI ratio and that both interventions reduced the rate of HO-CDI. This is the first report on the impact of hospital ward cleaning with PPED on the reduction of HO-CDI.Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Cross Infection
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Clostridioides difficile
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Clostridium Infections
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Disinfectants
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Antimicrobial Stewardship
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Anti-Infective Agents
Limits:
Humans
Language:
En
Journal:
J Hosp Infect
Year:
2022
Document type:
Article
Publication country:
ENGLAND
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ESCOCIA
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GB
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GREAT BRITAIN
/
INGLATERRA
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REINO UNIDO
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SCOTLAND
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UK
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UNITED KINGDOM