Recent advances in cytoplasmic lipid droplet metabolism in intestinal enterocyte.
Biochim Biophys Acta Mol Cell Biol Lipids
; 1867(10): 159197, 2022 10.
Article
in En
| MEDLINE
| ID: mdl-35820577
ABSTRACT
Processing of dietary fats in the intestine is a highly regulated process that influences whole-body energy homeostasis and multiple physiological functions. Dysregulated lipid handling in the intestine leads to dyslipidemia and atherosclerotic cardiovascular disease. In intestinal enterocytes, lipids are incorporated into lipoproteins and cytoplasmic lipid droplets (CLDs). Lipoprotein synthesis and CLD metabolism are inter-connected pathways with multiple points of regulation. This review aims to highlight recent advances in the regulatory mechanisms of lipid processing in the enterocyte, with particular focus on CLDs. In-depth understanding of the regulation of lipid metabolism in the enterocyte may help identify therapeutic targets for the treatment and prevention of metabolic disorders.
Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Enterocytes
/
Lipid Droplets
Language:
En
Journal:
Biochim Biophys Acta Mol Cell Biol Lipids
Year:
2022
Document type:
Article
Affiliation country:
Canada