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mRNA-LNP vaccines tuned for systemic immunization induce strong antitumor immunity by engaging splenic immune cells.
Bevers, Sanne; Kooijmans, Sander A A; Van de Velde, Elien; Evers, Martijn J W; Seghers, Sofie; Gitz-Francois, Jerney J J M; van Kronenburg, Nicky C H; Fens, Marcel H A M; Mastrobattista, Enrico; Hassler, Lucie; Sork, Helena; Lehto, Taavi; Ahmed, Kariem E; El Andaloussi, Samir; Fiedler, Katja; Breckpot, Karine; Maes, Michael; Van Hoorick, Diane; Bastogne, Thierry; Schiffelers, Raymond M; De Koker, Stefaan.
Affiliation
  • Bevers S; eTheRNA Immunotherapies, 2845 Niel, Belgium; Laboratory for Molecular and Cellular Therapy (LMCT), Free University of Brussels, 1090 Jette, Belgium.
  • Kooijmans SAA; CDL Research, University Medical Center Utrecht, 3508 GA Utrecht, the Netherlands.
  • Van de Velde E; eTheRNA Immunotherapies, 2845 Niel, Belgium.
  • Evers MJW; CDL Research, University Medical Center Utrecht, 3508 GA Utrecht, the Netherlands.
  • Seghers S; eTheRNA Immunotherapies, 2845 Niel, Belgium.
  • Gitz-Francois JJJM; CDL Research, University Medical Center Utrecht, 3508 GA Utrecht, the Netherlands.
  • van Kronenburg NCH; Department of Pharmaceutics, Utrecht Institute for Pharmaceutical Sciences, Utrecht University, 3584 CG Utrecht, the Netherlands.
  • Fens MHAM; Department of Pharmaceutics, Utrecht Institute for Pharmaceutical Sciences, Utrecht University, 3584 CG Utrecht, the Netherlands.
  • Mastrobattista E; Department of Pharmaceutics, Utrecht Institute for Pharmaceutical Sciences, Utrecht University, 3584 CG Utrecht, the Netherlands.
  • Hassler L; CYBERnano, 54000 Nancy, France.
  • Sork H; Institute of Technology, University of Tartu, 50411 Tartu, Estonia.
  • Lehto T; Institute of Technology, University of Tartu, 50411 Tartu, Estonia; Department of Laboratory Medicine, Karolinksa Institutet, 141 52 Huddinge, Sweden.
  • Ahmed KE; Department of Laboratory Medicine, Karolinksa Institutet, 141 52 Huddinge, Sweden.
  • El Andaloussi S; Department of Laboratory Medicine, Karolinksa Institutet, 141 52 Huddinge, Sweden.
  • Fiedler K; eTheRNA Immunotherapies, 2845 Niel, Belgium.
  • Breckpot K; Laboratory for Molecular and Cellular Therapy (LMCT), Free University of Brussels, 1090 Jette, Belgium.
  • Maes M; eTheRNA Immunotherapies, 2845 Niel, Belgium.
  • Van Hoorick D; eTheRNA Immunotherapies, 2845 Niel, Belgium.
  • Bastogne T; CYBERnano, 54000 Nancy, France; CRAN, Université de Lorraine, CNRS, INRIA BIGS, 54506 Vandœuvre-lès-Nancy, France.
  • Schiffelers RM; CDL Research, University Medical Center Utrecht, 3508 GA Utrecht, the Netherlands.
  • De Koker S; eTheRNA Immunotherapies, 2845 Niel, Belgium. Electronic address: stefaan.dekoker@etherna.be.
Mol Ther ; 30(9): 3078-3094, 2022 09 07.
Article in En | MEDLINE | ID: mdl-35821637
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Cancer Vaccines / Nanoparticles / COVID-19 Type of study: Qualitative_research Limits: Animals Language: En Journal: Mol Ther Journal subject: BIOLOGIA MOLECULAR / TERAPEUTICA Year: 2022 Document type: Article Affiliation country: Belgium
Fulltext
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Cancer Vaccines / Nanoparticles / COVID-19 Type of study: Qualitative_research Limits: Animals Language: En Journal: Mol Ther Journal subject: BIOLOGIA MOLECULAR / TERAPEUTICA Year: 2022 Document type: Article Affiliation country: Belgium