Characterization of transit rates in the large intestine of mice following treatment with a CGRP antibody, CGRP receptor antibody, and small molecule CGRP receptor antagonists.

Johnson, Kirk W; Li, Xia; Huang, Xiaofang; Heinz, Beverly A; Yu, Jianliang; Li, Baolin

Johnson, Kirk W; Li, Xia; Huang, Xiaofang; Heinz, Beverly A; Yu, Jianliang; Li, Baolin.

Affiliation

Johnson KW; Eli Lilly and Company, Lilly Corporate Center, Indianapolis, Indiana, USA.
Li X; Eli Lilly and Company, Lilly Corporate Center, Indianapolis, Indiana, USA.
Huang X; Eli Lilly and Company, Lilly Corporate Center, Indianapolis, Indiana, USA.
Heinz BA; Eli Lilly and Company, Lilly Corporate Center, Indianapolis, Indiana, USA.
Yu J; Eli Lilly and Company, Lilly Corporate Center, Indianapolis, Indiana, USA.
Li B; Eli Lilly and Company, Lilly Corporate Center, Indianapolis, Indiana, USA.

Headache ; 62(7): 848-857, 2022 07.

Article in En | MEDLINE | ID: mdl-35822594

Subject(s)

Calcitonin Gene-Related Peptide; Receptors, Calcitonin Gene-Related Peptide; Animals; Calcitonin Gene-Related Peptide Receptor Antagonists/pharmacology; Charcoal; Constipation; Female; Humans; Intestine, Large/metabolism; Ligands; Male; Mice; Mice, Transgenic; Piperidines; Pyridines; Pyrroles; Receptor Activity-Modifying Protein 1; Receptors, Calcitonin Gene-Related Peptide/metabolism; Spiro Compounds

Key words

CGRP; amylin; antibody; constipation; galcanezumab; gastrointestinal transit

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Calcitonin Gene-Related Peptide / Receptors, Calcitonin Gene-Related Peptide Limits: Animals / Female / Humans / Male Language: En Journal: Headache Year: 2022 Document type: Article Affiliation country: United States Country of publication: United States

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