A waterfall of susceptibility results: impact of microbiology testing cascade for MDROs.
Diagn Microbiol Infect Dis
; 104(1): 115731, 2022 Sep.
Article
in En
| MEDLINE
| ID: mdl-35841735
ABSTRACT
Cascade reporting is an antimicrobial stewardship strategy which selectively reports broad-spectrum antibiotic susceptibility when narrower-spectrum agents are resistant. Three regional laboratories, which provide microbiology services for HCA Healthcare hospitals in Florida, implemented a standardized antibiotic testing cascade for multi-drug resistant organisms. This study evaluated the impact of the testing cascade on time to susceptibility results for carbapenem-resistant Gram-negative organisms. Appropriateness of manual susceptibility test selection was also assessed. Compliance with the testing cascade was 56%. Appropriateness of manual tests in the pre- and post-intervention groups was 87% (257/297) and 96% (310/323), respectively (P < 0.0001). Median time to first manual test result was 23.1 hours (IQR 19.8-25.2 hours) in the pre-intervention group and 23.9 hours (IQR 20.2-27.0 hours) in the post-intervention group (P = 0.11). Implementation of a testing cascade did not result in faster manual susceptibility results, however there was a significant increase in testing appropriateness.
Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Antimicrobial Stewardship
/
Anti-Bacterial Agents
Limits:
Humans
Language:
En
Journal:
Diagn Microbiol Infect Dis
Year:
2022
Document type:
Article