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Favorable prognostic phenotype in myelodysplastic syndrome with der(1;7)(q10;p10).
Horio, Tomohiro; Enomoto, Megumi; Watarai, Masaya; Nakano, Yuuta; Yamada, Saki; Matsumura, Saori; Kanasugi, Jo; Takasugi, Soichi; Nakamura, Ayano; Uchino, Kaori; Mizuno, Shohei; Murakami, Satsuki; Yamamoto, Hidesuke; Hanamura, Ichiro; Takami, Akiyoshi.
Affiliation
  • Horio T; Division of Hematology Department of Internal Medicine School of Medicine Aichi Medical University Nagakute Japan.
  • Enomoto M; Hematopoietic Cell Transplantation Center Aichi Medical University Hospital Nagakute Japan.
  • Watarai M; Department of Clinical Laboratory Aichi Medical University Hospital Nagakute Japan.
  • Nakano Y; Department of Hematology and Chemotherapy Daido Hospital Nagoya Japan.
  • Yamada S; Division of Hematology Department of Internal Medicine School of Medicine Aichi Medical University Nagakute Japan.
  • Matsumura S; Hematopoietic Cell Transplantation Center Aichi Medical University Hospital Nagakute Japan.
  • Kanasugi J; Department of Hematology and Chemotherapy Daido Hospital Nagoya Japan.
  • Takasugi S; Division of Hematology Department of Internal Medicine School of Medicine Aichi Medical University Nagakute Japan.
  • Nakamura A; Hematopoietic Cell Transplantation Center Aichi Medical University Hospital Nagakute Japan.
  • Uchino K; Division of Hematology Department of Internal Medicine School of Medicine Aichi Medical University Nagakute Japan.
  • Mizuno S; Hematopoietic Cell Transplantation Center Aichi Medical University Hospital Nagakute Japan.
  • Murakami S; Division of Hematology Department of Internal Medicine School of Medicine Aichi Medical University Nagakute Japan.
  • Yamamoto H; Hematopoietic Cell Transplantation Center Aichi Medical University Hospital Nagakute Japan.
  • Hanamura I; Division of Hematology Department of Internal Medicine School of Medicine Aichi Medical University Nagakute Japan.
  • Takami A; Hematopoietic Cell Transplantation Center Aichi Medical University Hospital Nagakute Japan.
EJHaem ; 1(2): 558-562, 2020 Nov.
Article in En | MEDLINE | ID: mdl-35844998
ABSTRACT
Unbalanced translocation der(1;7)(q10;p10) is a characteristic chromosomal abnormality in myelodysplastic syndrome (MDS). The current study revealed that among 13 MDS patients with der(1;7)(q10;p10), seven cases with no apparent dysplasia also had low numbers of myeloblasts in the bone marrow and a 3-year survival rate of 86%; in contrast, the remaining six cases had a 3-year survival rate of 0% (P = .003). It was therefore suggested that MDS patients with der(1;7)(q10;p10) are classified into a distinct group with a favorable prognosis and another distinct group with a very poor prognosis.
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Full text: 1 Collection: 01-internacional Database: MEDLINE Type of study: Prognostic_studies Language: En Journal: EJHaem Year: 2020 Document type: Article Publication country: EEUU / ESTADOS UNIDOS / ESTADOS UNIDOS DA AMERICA / EUA / UNITED STATES / UNITED STATES OF AMERICA / US / USA
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Full text: 1 Collection: 01-internacional Database: MEDLINE Type of study: Prognostic_studies Language: En Journal: EJHaem Year: 2020 Document type: Article Publication country: EEUU / ESTADOS UNIDOS / ESTADOS UNIDOS DA AMERICA / EUA / UNITED STATES / UNITED STATES OF AMERICA / US / USA