Long-term outcome of immunologic autograft engineering.
EJHaem
; 3(2): 488-491, 2022 May.
Article
in En
| MEDLINE
| ID: mdl-35846064
ABSTRACT
Our phase III trial reported that autograft-absolute lymphocyte count (A-ALC) improved survival post-autologous peripheral blood hematopoietic stem cell transplantation (APBHSCT) for a short-term follow-up of 2 years. We evaluated retrospectively in our phase III trial patients that the A-ALC still confers survival benefit with a longer follow-up. With a median follow-up of 127.6 months, patients infused with an A-ALC ≥ 0.5 × 109 cells/kg experienced better overall survival (HR = 0.392, 95% confidence of interval [CI] 0.224-0.687, p < 0.001) and progression-free survival (HR = 0.413, 95% CI 0.253-0.677), p < 0.0004). This study supports that A-ALC provides long-term survival benefit post APBHSCT.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Language:
En
Journal:
EJHaem
Year:
2022
Document type:
Article