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Treating allergies via skin - Recent advances in cutaneous allergen immunotherapy.
Nesovic, Lazar D; Shakya, Akhilesh K; Gill, Harvinder S.
Affiliation
  • Nesovic LD; Department of Chemical Engineering, Texas Tech University, 8th and Canton, Lubbock, TX 79409, United States.
  • Shakya AK; Department of Chemical Engineering, Texas Tech University, 8th and Canton, Lubbock, TX 79409, United States.
  • Gill HS; Department of Chemical Engineering, Texas Tech University, 8th and Canton, Lubbock, TX 79409, United States. Electronic address: harvinder.gill@ttu.edu.
Adv Drug Deliv Rev ; 190: 114458, 2022 11.
Article in En | MEDLINE | ID: mdl-35850371
Subcutaneous allergen immunotherapy has been practiced clinically for decades to treat airborne allergies. Recently, the cutaneous route, which exploits the immunocompetence of the skin has received attention, which is evident from attempts to use it to treat peanut allergy. Delivery of allergens into the skin is inherently impeded by the barrier imposed by stratum corneum, the top layer of the skin. While the stratum corneum barrier must be overcome for efficient allergen delivery, excessive disruption of this layer can predispose to development of allergic inflammation. Thus, the most desirable allergen delivery approach must provide a balance between the level of skin disruption and the amount of allergen delivered. Such an approach should aim to achieve high allergen delivery efficiency across various skin types independent of age and ethnicity, and optimize variables such as safety profile, allergen dosage, treatment frequency, application time and patient compliance. The ability to precisely quantify the amount of allergen being delivered into the skin is crucial since it can allow for allergen dose optimization and can promote consistency and reproducibility in treatment response. In this work we review prominent cutaneous delivery approaches, and offer a perspective on further improvisation in cutaneous allergen-specific immunotherapy.
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Desensitization, Immunologic / Peanut Hypersensitivity Limits: Humans Language: En Journal: Adv Drug Deliv Rev Journal subject: FARMACOLOGIA / TERAPIA POR MEDICAMENTOS Year: 2022 Document type: Article Affiliation country: United States Country of publication: Netherlands

Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Desensitization, Immunologic / Peanut Hypersensitivity Limits: Humans Language: En Journal: Adv Drug Deliv Rev Journal subject: FARMACOLOGIA / TERAPIA POR MEDICAMENTOS Year: 2022 Document type: Article Affiliation country: United States Country of publication: Netherlands