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Contemporary perspectives on heterotopic ossification.
Hwang, Charles D; Pagani, Chase A; Nunez, Johanna H; Cherief, Masnsen; Qin, Qizhi; Gomez-Salazar, Mario; Kadaikal, Balram; Kang, Heeseog; Chowdary, Ashish R; Patel, Nicole; James, Aaron W; Levi, Benjamin.
Affiliation
  • Hwang CD; Division of Plastic and Reconstructive Surgery, Department of Surgery, Massachusetts General Hospital, Harvard University, Boston, Massachusetts, USA.
  • Pagani CA; Department of Surgery, Center for Organogenesis Research and Trauma, University of Texas Southwestern Medical Center, Dallas, Texas, USA.
  • Nunez JH; Department of Surgery, Center for Organogenesis Research and Trauma, University of Texas Southwestern Medical Center, Dallas, Texas, USA.
  • Cherief M; Department of Pathology, Johns Hopkins University, Baltimore, Maryland, USA.
  • Qin Q; Department of Pathology, Johns Hopkins University, Baltimore, Maryland, USA.
  • Gomez-Salazar M; Department of Pathology, Johns Hopkins University, Baltimore, Maryland, USA.
  • Kadaikal B; Department of Surgery, Center for Organogenesis Research and Trauma, University of Texas Southwestern Medical Center, Dallas, Texas, USA.
  • Kang H; Department of Surgery, Center for Organogenesis Research and Trauma, University of Texas Southwestern Medical Center, Dallas, Texas, USA.
  • Chowdary AR; Department of Surgery, Center for Organogenesis Research and Trauma, University of Texas Southwestern Medical Center, Dallas, Texas, USA.
  • Patel N; Division of Plastic and Reconstructive Surgery, Department of Surgery, University of Michigan, Ann Arbor, Michigan, USA.
  • James AW; Department of Pathology, Johns Hopkins University, Baltimore, Maryland, USA.
  • Levi B; Department of Surgery, Center for Organogenesis Research and Trauma, University of Texas Southwestern Medical Center, Dallas, Texas, USA.
JCI Insight ; 7(14)2022 07 22.
Article in En | MEDLINE | ID: mdl-35866484
ABSTRACT
Heterotopic ossification (HO) is the formation of ectopic bone that is primarily genetically driven (fibrodysplasia ossificans progressiva [FOP]) or acquired in the setting of trauma (tHO). HO has undergone intense investigation, especially over the last 50 years, as awareness has increased around improving clinical technologies and incidence, such as with ongoing wartime conflicts. Current treatments for tHO and FOP remain prophylactic and include NSAIDs and glucocorticoids, respectively, whereas other proposed therapeutic modalities exhibit prohibitive risk profiles. Contemporary studies have elucidated mechanisms behind tHO and FOP and have described new distinct niches independent of inflammation that regulate ectopic bone formation. These investigations have propagated a paradigm shift in the approach to treatment and management of a historically difficult surgical problem, with ongoing clinical trials and promising new targets.
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Ossification, Heterotopic / Myositis Ossificans Type of study: Etiology_studies Limits: Humans Language: En Journal: JCI Insight Year: 2022 Document type: Article Affiliation country: United States
Fulltext
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Ossification, Heterotopic / Myositis Ossificans Type of study: Etiology_studies Limits: Humans Language: En Journal: JCI Insight Year: 2022 Document type: Article Affiliation country: United States