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The Need for Individualized Risk Assessment in Cardiovascular Disease.
Lim, Hui Yin; Burrell, Louise M; Brook, Rowena; Nandurkar, Harshal H; Donnan, Geoffrey; Ho, Prahlad.
Affiliation
  • Lim HY; Northern Pathology Victoria, Northern Health, Epping, Melbourne, VIC 3076, Australia.
  • Burrell LM; Department of Hematology, Northern Health, Epping, Melbourne, VIC 3076, Australia.
  • Brook R; Australian Centre for Blood Diseases, Monash University, Melbourne, VIC 3004, Australia.
  • Nandurkar HH; Department of Medicine, Northern Health, University of Melbourne, Epping, Melbourne, VIC 3076, Australia.
  • Donnan G; Department of Medicine, Austin Health, University of Melbourne, Heidelberg, Melbourne, VIC 3084, Australia.
  • Ho P; Department of Medicine, Austin Health, University of Melbourne, Heidelberg, Melbourne, VIC 3084, Australia.
J Pers Med ; 12(7)2022 Jul 14.
Article in En | MEDLINE | ID: mdl-35887637
Cardiovascular disease remains the leading cause of death in the era of modern medicine despite major advancements in this field. Current available clinical surrogate markers and blood tests do not adequately predict individual risk of cardiovascular disease. A more precise and sophisticated tool that can reliably predict the thrombosis and bleeding risks at an individual level is required in order for clinicians to confidently recommend early interventions with a favorable risk-benefit profile. Critical to the development of this tool is the assessment and understanding of Virchow's triad and its complex interactions between hypercoagulability, endothelial dysfunction and vessel flow, a fundamental concept to the development of thrombosis. This review explores the pathophysiology of cardiovascular disease stemming from the triad of factors and how individualized risk assessment can be improved through the multimodal use of tools such as global coagulation assays, endothelial biomarkers and vessel flow assessment.
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Full text: 1 Collection: 01-internacional Database: MEDLINE Type of study: Etiology_studies / Prognostic_studies / Risk_factors_studies Language: En Journal: J Pers Med Year: 2022 Document type: Article Affiliation country: Australia Country of publication: Switzerland

Full text: 1 Collection: 01-internacional Database: MEDLINE Type of study: Etiology_studies / Prognostic_studies / Risk_factors_studies Language: En Journal: J Pers Med Year: 2022 Document type: Article Affiliation country: Australia Country of publication: Switzerland