Associations of serum long-chain fatty acids with multiple organ involvement in patients with sarcoidosis.
BMC Pulm Med
; 22(1): 290, 2022 Jul 28.
Article
in En
| MEDLINE
| ID: mdl-35902843
ABSTRACT
BACKGROUND:
Fatty acids have diverse immunomodulatory functions and the potential to be associated with inflammatory responses in sarcoidosis.METHODS:
The serum levels of multiple long-chain fatty acids (LCFAs) were compared between 63 patients with sarcoidosis and 38 healthy controls. The associations of LCFAs with clinical outcomes of sarcoidosis were also evaluated.RESULTS:
The patients with sarcoidosis had significantly lower levels of n-3 poly-unsaturated fatty acids (PUFAs) (p < 0.001) and n-6 PUFAs (p < 0.001) than the healthy controls. However, there were no significant differences in the levels of saturated fatty acids (SFAs) and mono-unsaturated fatty acids (MUFAs) between the two groups. On multivariate logistic analysis, lower levels of n-3 PUFAs, n-6 PUFAs, and n-3/n-6 ratio were predictive of sarcoidosis. Among the patients with sarcoidosis, those with multiple organ involvement had significantly lower levels of n-3 PUFAs and n-3/n-6 ratio than those with single organ involvement. There were no significant differences in the levels of n-6 PUFAs, SFAs, and MUFAs between the patients with multiple and single organ involvement. On multivariate logistic analysis, lower levels of SFAs and n-3/n-6 ratio were predictive of multiple organ involvement. The levels of LCFAs had no significant association with radiographic stage or spontaneous remission.CONCLUSIONS:
Assessment of LCFA profiles may be useful for the diagnosis of sarcoidosis and evaluation of the disease activity.Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Sarcoidosis
/
Fatty Acids, Omega-3
Type of study:
Prognostic_studies
/
Risk_factors_studies
Limits:
Humans
Language:
En
Journal:
BMC Pulm Med
Year:
2022
Document type:
Article
Affiliation country:
Japan