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The effect of immunosuppression or thymectomy on the response to tetanus revaccination in myasthenia gravis.
Strijbos, Ellen; van Ostaijen-Ten Dam, Monique M; Vervat, Carly; Schilham, Marco W; Huijbers, Maartje G M; van Tol, Maarten J D; Verschuuren, Jan J G M.
Affiliation
  • Strijbos E; Department of Neurology, Leiden University Medical Centre, the Netherlands. Electronic address: e.strijbos@lumc.nl.
  • van Ostaijen-Ten Dam MM; Department of Paediatrics, Laboratory of Immunology, Leiden University Medical Centre, the Netherlands.
  • Vervat C; Department of Paediatrics, Laboratory of Immunology, Leiden University Medical Centre, the Netherlands.
  • Schilham MW; Department of Paediatrics, Laboratory of Immunology, Leiden University Medical Centre, the Netherlands.
  • Huijbers MGM; Department of Neurology, Leiden University Medical Centre, the Netherlands; Department of Human Genetics, Leiden University Medical Centre.
  • van Tol MJD; Department of Paediatrics, Laboratory of Immunology, Leiden University Medical Centre, the Netherlands.
  • Verschuuren JJGM; Department of Neurology, Leiden University Medical Centre, the Netherlands.
J Neuroimmunol ; 370: 577930, 2022 09 15.
Article in En | MEDLINE | ID: mdl-35905614
ABSTRACT

OBJECTIVE:

To determine the effect of tetanus toxoid (TT) revaccination on circulating B-, T- and NK-cell compartments in myasthenia gravis (MG) patients.

METHODS:

Lymphocyte (sub)populations and differentiation stages were assessed by flow cytometry in 50 TT revaccinated MG patients. TT-specific proliferative responses were explored in PBMC cultures.

RESULTS:

In patients treated with azathioprine B- and NK cell numbers were strongly decreased. Lymphocyte (sub)populations remained unaffected upon TT revaccination. t All patients showed a significant TT-induced proliferative response.

CONCLUSION:

TT revaccination is effective in MG patients with stable disease irrespective of their thymectomy status and medication and does not alter the composition of the lymphocyte compartment.
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Tetanus / Myasthenia Gravis Limits: Humans Language: En Journal: J Neuroimmunol Year: 2022 Document type: Article
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Tetanus / Myasthenia Gravis Limits: Humans Language: En Journal: J Neuroimmunol Year: 2022 Document type: Article