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A NIR molecular rotor photosensitizer for efficient PDT and synchronous mitochondrial viscosity imaging.
Yang, Liu; Chen, Qingxin; Wan, Yingpeng; Gan, Shenglong; Li, Shengliang; Lee, Chun-Sing; Jiang, Yin; Zhang, Huatang; Sun, Hongyan.
Affiliation
  • Yang L; College of Chemistry and Chemical Engineering, Central South University, Changsha, Hunan, 410083, P. R. China. yangliu92@csu.edu.cn.
  • Chen Q; Department of Chemistry and COSDAF (Centre of Super-Diamond and Advanced Films), City University of Hong Kong, 83 Tat Chee Avenue, Kowloon, Hong Kong, China. hongysun@cityu.edu.hk.
  • Wan Y; Department of Chemistry and COSDAF (Centre of Super-Diamond and Advanced Films), City University of Hong Kong, 83 Tat Chee Avenue, Kowloon, Hong Kong, China. hongysun@cityu.edu.hk.
  • Gan S; Key Laboratory of Biochip Technology, Biotech and Health Centre, Shenzhen Research Institute of City University of Hong Kong, Shenzhen, 518057, P. R. China.
  • Li S; Department of Chemistry and COSDAF (Centre of Super-Diamond and Advanced Films), City University of Hong Kong, 83 Tat Chee Avenue, Kowloon, Hong Kong, China. hongysun@cityu.edu.hk.
  • Lee CS; Department of Chemistry and COSDAF (Centre of Super-Diamond and Advanced Films), City University of Hong Kong, 83 Tat Chee Avenue, Kowloon, Hong Kong, China. hongysun@cityu.edu.hk.
  • Jiang Y; Key Laboratory of Biochip Technology, Biotech and Health Centre, Shenzhen Research Institute of City University of Hong Kong, Shenzhen, 518057, P. R. China.
  • Zhang H; Department of Chemistry and COSDAF (Centre of Super-Diamond and Advanced Films), City University of Hong Kong, 83 Tat Chee Avenue, Kowloon, Hong Kong, China. hongysun@cityu.edu.hk.
  • Sun H; Department of Chemistry and COSDAF (Centre of Super-Diamond and Advanced Films), City University of Hong Kong, 83 Tat Chee Avenue, Kowloon, Hong Kong, China. hongysun@cityu.edu.hk.
Chem Commun (Camb) ; 58(67): 9425-9428, 2022 Aug 18.
Article in En | MEDLINE | ID: mdl-35916476
ABSTRACT
Herein, two mitochondria-targeting photosensitizers (PSs, CCVJ-Mito-1 and CCVJ-Mito-2) that exhibit a turn-on fluorescence response towards increasing viscosity are reported. Notably, CCVJ-Mito-2 exhibits absorption in the near-infrared (NIR) region, and can be employed as a NIR PS targeting mitochondria and a fluorescent probe for tracking mitochondrial viscosity changes during photodynamic therapy (PDT). This dual functional PS can help to shed light on the dynamic changes of the cellular microenvironment during PDT and further guide the PDT process.
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Photochemotherapy / Photosensitizing Agents Language: En Journal: Chem Commun (Camb) Journal subject: QUIMICA Year: 2022 Document type: Article
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Photochemotherapy / Photosensitizing Agents Language: En Journal: Chem Commun (Camb) Journal subject: QUIMICA Year: 2022 Document type: Article