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Key difference between transition state stabilization and ground state destabilization: increasing atomic charge densities before or during enzyme-substrate binding.
Chen, Deliang; Li, Yibao; Li, Xun; Hong, Xuechuan; Fan, Xiaolin; Savidge, Tor.
Affiliation
  • Chen D; Jiangxi Key Laboratory of Organo-Pharmaceutical Chemistry, Chemistry and Chemical Engineering College, Gannan Normal University Ganzhou Jiangxi 341000 China deliang2211@hotmail.com.
  • Li Y; Jiangxi Key Laboratory of Organo-Pharmaceutical Chemistry, Chemistry and Chemical Engineering College, Gannan Normal University Ganzhou Jiangxi 341000 China deliang2211@hotmail.com.
  • Li X; Jiangxi Key Laboratory of Organo-Pharmaceutical Chemistry, Chemistry and Chemical Engineering College, Gannan Normal University Ganzhou Jiangxi 341000 China deliang2211@hotmail.com.
  • Hong X; State Key Laboratory of Virology, Key Laboratory of Combinatorial Biosynthesis and Drug Discovery and Hubei Province, Wuhan University School of Pharmaceutical Sciences Wuhan 430071 China.
  • Fan X; Jiangxi Key Laboratory of Organo-Pharmaceutical Chemistry, Chemistry and Chemical Engineering College, Gannan Normal University Ganzhou Jiangxi 341000 China deliang2211@hotmail.com.
  • Savidge T; Department of Pathology & Immunology, Baylor College of Medicine Houston TX 77030 USA tor.savidge@bcm.edu.
Chem Sci ; 13(27): 8193-8202, 2022 Jul 13.
Article in En | MEDLINE | ID: mdl-35919436
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Full text: 1 Collection: 01-internacional Database: MEDLINE Language: En Journal: Chem Sci Year: 2022 Document type: Article Country of publication: United kingdom
Fulltext
Add to My VHL
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XML
PubMed Links
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Full text: 1 Collection: 01-internacional Database: MEDLINE Language: En Journal: Chem Sci Year: 2022 Document type: Article Country of publication: United kingdom