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Diamond-Blackfan anaemia with iron overload: A serious issue.
Quarello, Paola; Ramenghi, Ugo; Fagioli, Franca.
Affiliation
  • Quarello P; Pediatric Onco-Hematology, Stem Cell Transplantation and Cellular Therapy Division, Regina Margherita Children's Hospital, Azienda Ospedaliera-Universitaria Città della Salute e della Scienza, University of Torino, Torino, Italy.
  • Ramenghi U; Department of Pediatric and Public Health Sciences, University of Turin, Turin, Italy.
  • Fagioli F; Pediatric Onco-Hematology, Stem Cell Transplantation and Cellular Therapy Division, Regina Margherita Children's Hospital, Azienda Ospedaliera-Universitaria Città della Salute e della Scienza, University of Torino, Torino, Italy.
Br J Haematol ; 199(2): 171-172, 2022 10.
Article in En | MEDLINE | ID: mdl-35929529
ABSTRACT
Transfusion-dependent Diamond-Blackfan anaemia (DBA) patients rapidly develop iron overload and frequently experience cardiac complications. The report by Lecornec and colleagues offers useful details on indications and the management of deferiprone, a highly efficient chelator in removing excess cardiac iron but associated with a high risk of agranulocytosis in DBA patients. Commentary on Lecornec et al. Agranulocytosis in patients with Diamond-Blackfan anaemia (DBA) treated with deferiprone for post-transfusion iron overload A retrospective study of the French DBA cohort. British Journal of Haematology 2022;199285-288.
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Iron Overload / Anemia, Diamond-Blackfan / Agranulocytosis Type of study: Observational_studies / Risk_factors_studies Limits: Humans Language: En Journal: Br J Haematol Year: 2022 Document type: Article Affiliation country: Italy
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Iron Overload / Anemia, Diamond-Blackfan / Agranulocytosis Type of study: Observational_studies / Risk_factors_studies Limits: Humans Language: En Journal: Br J Haematol Year: 2022 Document type: Article Affiliation country: Italy