Positive allosteric modulators of GABA<sub>A</sub> receptor restore chloride current from blockade by competitive antagonists in a ligand-dependent manner.

Bukanova, Julia V; Kondratenko, Rodion V; Solntseva, Elena I

Positive allosteric modulators of GABA_A receptor restore chloride current from blockade by competitive antagonists in a ligand-dependent manner.

Bukanova, Julia V; Kondratenko, Rodion V; Solntseva, Elena I.

Affiliation

Bukanova JV; Research Center of Neurology, Moscow, Russia. Electronic address: julia@fast-mail.org.
Kondratenko RV; Research Center of Neurology, Moscow, Russia. Electronic address: kondrat_r@mail.ru.
Solntseva EI; Research Center of Neurology, Moscow, Russia. Electronic address: synaptology@mail.ru.

J Steroid Biochem Mol Biol ; 224: 106158, 2022 11.

Article in En | MEDLINE | ID: mdl-35931327

Subject(s)

Chlorides; Receptors, GABA-A; Rats; Animals; Receptors, GABA-A/chemistry; Chlorides/metabolism; Ligands; gamma-Aminobutyric Acid/metabolism; gamma-Aminobutyric Acid/pharmacology; Pregnanolone/pharmacology; GABA-A Receptor Antagonists/pharmacology

Key words

Allopregnanolone; Bicuculline; GABA(A)-receptor; Gabazine; Patch-clamp; Zolpidem

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Chlorides / Receptors, GABA-A Limits: Animals Language: En Journal: J Steroid Biochem Mol Biol Journal subject: BIOLOGIA MOLECULAR / BIOQUIMICA Year: 2022 Document type: Article Country of publication: United kingdom

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