Indocyanine green fluorescence-guided surgery in head and neck cancer: A systematic review.
Am J Otolaryngol
; 43(5): 103570, 2022.
Article
in En
| MEDLINE
| ID: mdl-35939987
ABSTRACT
OBJECTIVE:
To assess the feasibility and effectiveness of indocyanine green (ICG) for image-guided resection of head and neck cancer (HNC). DATA SOURCES PubMed, Embase, and Scopus databases. REVIEWMETHODS:
Searches were conducted from database inception to February 2022. Patient and study characteristics, imaging parameters, and imaging efficacy data were extracted from each study.RESULTS:
Nine studies met inclusion criteria, representing 103 head and neck tumors. Weighted mean ICG dose and imaging time were 1.27 mg/kg and 11.77 h, respectively. Among the five studies that provided quantitative metrics of imaging efficacy, average ICG tumor-to-background ratio (TBR) was 1.56 and weighted mean ONM-100 TBR was 3.64. Pooled sensitivity and specificity across the five studies were 91.7 % and 71.9 %, respectively.CONCLUSION:
FGS with ICG may facilitate real-time tumor-margin delineation to improve margin clearance rates and progression-free survival. Future studies with validated, quantitative metrics of imaging success are necessary to further evaluate the prognostic benefit of these techniques.Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Surgery, Computer-Assisted
/
Head and Neck Neoplasms
Type of study:
Prognostic_studies
/
Systematic_reviews
Limits:
Humans
Language:
En
Journal:
Am J Otolaryngol
Year:
2022
Document type:
Article
Affiliation country:
United States