Steroid therapy has an acceptable role as the initial treatment in autoimmune pancreatitis patients with pancreatic cyst formation: Based on a Japanese nationwide study.
J Hepatobiliary Pancreat Sci
; 30(5): 664-677, 2023 May.
Article
in En
| MEDLINE
| ID: mdl-35950952
ABSTRACT
BACKGROUND:
We attempted to determine the indications and limitations of steroid therapy as the first-line therapy in patients with autoimmune pancreatitis (AIP) with cyst formation (ACF).METHODS:
This Japanese multicenter survey was conducted to examine the merits/demerits of steroid treatment as the initial therapy for ACF.RESULTS:
Data of a total of 115 patients with ACF were analyzed. Complete remission was achieved in 86% (86/100) of patients who had received steroid treatment, but only 33.3% (5/15) of patients who had not received steroids. Relapse after the remission (n = 86) occurred in 7.6% (6/86) of patients who had received steroid therapy, but 40% (2/5) of patients who had not received steroid therapy. Multivariate analysis identified adoption of the wait and watch approach without steroid treatment (odds ratio = 0.126, P < .001) as a significant and independent negative predictor of remission of ACF. As for predictors of relapse, the presence of varix (odds ratio = 5.83, P = .036) was identified as an independent risk factor.CONCLUSION:
Steroid therapy plays an important role as first-line therapy in AIP patients with pancreatic cyst formation, however, varix formation, besides the diameter of the cyst(s), is a risk factor for refractoriness to steroid therapy.Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Pancreatic Cyst
/
Autoimmune Diseases
/
Autoimmune Pancreatitis
Type of study:
Prognostic_studies
Limits:
Humans
Language:
En
Journal:
J Hepatobiliary Pancreat Sci
Year:
2023
Document type:
Article
Affiliation country:
Japan