Senolytic drugs relieve pain by reducing peripheral nociceptive signaling without modifying joint tissue damage in spontaneous osteoarthritis.

Gil, Tae-Hwan; Zheng, Haiyan; Lee, Hyo Gyeong; Shin, Ji-Won; Hwang, Sun Wook; Jang, Ki-Mo; Jeon, Ok Hee

Gil, Tae-Hwan; Zheng, Haiyan; Lee, Hyo Gyeong; Shin, Ji-Won; Hwang, Sun Wook; Jang, Ki-Mo; Jeon, Ok Hee.

Affiliation

Gil TH; Department of Biomedical Sciences, College of Medicine, Korea University, Seoul 02841, Republic of Korea.
Zheng H; Department of Biomedical Sciences, College of Medicine, Korea University, Seoul 02841, Republic of Korea.
Lee HG; Department of Physiology, College of Medicine, Korea University, Seoul 02841, Republic of Korea.
Shin JW; Department of Biomedical Sciences, College of Medicine, Korea University, Seoul 02841, Republic of Korea.
Hwang SW; Department of Biomedical Sciences, College of Medicine, Korea University, Seoul 02841, Republic of Korea.
Jang KM; Department of Biomedical Sciences, College of Medicine, Korea University, Seoul 02841, Republic of Korea.
Jeon OH; Department of Physiology, College of Medicine, Korea University, Seoul 02841, Republic of Korea.

Aging (Albany NY) ; 14(15): 6006-6027, 2022 Aug 10.

Article in En | MEDLINE | ID: mdl-35951358

Subject(s)

Nerve Growth Factor; Osteoarthritis; Animals; Humans; Mice; Nociception; Osteoarthritis/metabolism; Pain; Pharmaceutical Preparations; Senotherapeutics

Key words

nociceptive pathways; pain; senescence; senolytics; spontaneous osteoarthritis

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Osteoarthritis / Nerve Growth Factor Type of study: Guideline / Prognostic_studies / Risk_factors_studies Limits: Animals / Humans Language: En Journal: Aging (Albany NY) Journal subject: GERIATRIA Year: 2022 Document type: Article Country of publication: United States

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