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Imbalance between alpha-1-antitrypsin and interleukin 6 is associated with in-hospital mortality and thrombosis during COVID-19.
Philippe, Aurélien; Puel, Mathilde; Narjoz, Céline; Gendron, Nicolas; Durey-Dragon, Marie Agnès; Vedie, Benoit; Balduyck, Malika; Chocron, Richard; Hauw-Berlemont, Caroline; Sanchez, Olivier; Mirault, Tristan; Diehl, Jean-Luc; Smadja, David M; Loriot, Marie Anne.
Affiliation
  • Philippe A; Université de Paris Cité, Innovative Therapies in Haemostasis, INSERM, Paris, France; Hematology Department and Biosurgical Research Lab (Carpentier Foundation), Assistance Publique Hôpitaux de Paris-Centre (APHP-CUP), Paris, France. Electronic address: aurelien.philippe@aphp.fr.
  • Puel M; Department of Clinical Chemistry, Hôpital Européen Georges Pompidou, Université of Paris Cité, Assistance Publique Hôpitaux de Paris-Centre (APHP-CUP), Paris, France.
  • Narjoz C; Department of Clinical Chemistry, Hôpital Européen Georges Pompidou, Université of Paris Cité, Assistance Publique Hôpitaux de Paris-Centre (APHP-CUP), Paris, France.
  • Gendron N; Université de Paris Cité, Innovative Therapies in Haemostasis, INSERM, Paris, France; Hematology Department and Biosurgical Research Lab (Carpentier Foundation), Assistance Publique Hôpitaux de Paris-Centre (APHP-CUP), Paris, France.
  • Durey-Dragon MA; Centre de Recherche des Cordeliers, Sorbonne Université, INSERM, Université de Paris Cité, Team Inflammation, Complement and Cancer, and Immunology Department, Georges Pompidou European Hospital, APHP-CUP, F-75015, Paris, France.
  • Vedie B; Department of Clinical Chemistry, Hôpital Européen Georges Pompidou, Université of Paris Cité, Assistance Publique Hôpitaux de Paris-Centre (APHP-CUP), Paris, France.
  • Balduyck M; CHU Lille, Laboratoire de Biochimie « Hormonologie, Metabolisme, Nutrition-Oncologie ¼, Lille, France; CHU Lille, Univ Lille, INSERM UMR 1285, Institut de Microbiologie, Lille, France.
  • Chocron R; Université de Paris Cité, PARCC, INSERM, F-75015, Emergency Department, APHP-CUP, F-75015, Paris, France.
  • Hauw-Berlemont C; Réanimation Médicale, Hôpital Européen Georges Pompidou, 26930Assistance Publique des Hôpitaux de Paris (AP-HP), Paris, France.
  • Sanchez O; Respiratory Medicine Department and Biosurgical Research Lab (Carpentier Foundation), Assistance Publique Hôpitaux de Paris-Centre (APHP-CUP), Paris, France.
  • Mirault T; Vascular Medicine Department and Georges Pompidou European Hospital, AP-HP, 75015, Paris, France; PARCC, INSERM, Université de Paris, 75015, Paris, France.
  • Diehl JL; Université de Paris Cité, Innovative Therapies in Haemostasis, INSERM, Paris, France; Intensive Care Unit and Biosurgical Research Lab (Carpentier Foundation), Assistance Publique - Hôpitaux de Paris-Centre (APHP-CUP), Paris, France.
  • Smadja DM; Université de Paris Cité, Innovative Therapies in Haemostasis, INSERM, Paris, France; Hematology Department and Biosurgical Research Lab (Carpentier Foundation), Assistance Publique Hôpitaux de Paris-Centre (APHP-CUP), Paris, France.
  • Loriot MA; Department of Clinical Chemistry, Hôpital Européen Georges Pompidou, Université of Paris Cité, Assistance Publique Hôpitaux de Paris-Centre (APHP-CUP), Paris, France; INSERM UMR-S1138, Centre de recherches des Cordeliers, Paris, France. Electronic address: marie-anne.loriot@aphp.fr.
Biochimie ; 202: 206-211, 2022 Nov.
Article in En | MEDLINE | ID: mdl-35952950
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Thrombosis / Alpha 1-Antitrypsin / Interleukin-6 / Hospital Mortality / COVID-19 Type of study: Observational_studies / Prevalence_studies / Prognostic_studies / Risk_factors_studies Limits: Humans Language: En Journal: Biochimie Year: 2022 Document type: Article Country of publication: France
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Thrombosis / Alpha 1-Antitrypsin / Interleukin-6 / Hospital Mortality / COVID-19 Type of study: Observational_studies / Prevalence_studies / Prognostic_studies / Risk_factors_studies Limits: Humans Language: En Journal: Biochimie Year: 2022 Document type: Article Country of publication: France