Whole-body inhalation of nano-sized carbon black: a surrogate model of military burn pit exposure.
BMC Res Notes
; 15(1): 275, 2022 Aug 11.
Article
in En
| MEDLINE
| ID: mdl-35953874
ABSTRACT
OBJECTIVE:
Chronic multisymptom illness (CMI) is an idiopathic disease affecting thousands of U.S. Veterans exposed to open-air burn pits emitting aerosolized particulate matter (PM) while serving in Central and Southwest Asia and Africa. Exposure to burn pit PM can result in profound biologic consequences including chronic fatigue, impaired cognition, and respiratory diseases. Dysregulated or unresolved inflammation is a possible underlying mechanism for CMI onset. We describe a rat model of whole-body inhalation exposure using carbon black nanoparticles (CB) as a surrogate for military burn pit-related exposure. Using this model, we measured biomarkers of inflammation in multiple tissues.RESULTS:
Male Sprague Dawley rats were exposed to CB aerosols by whole body inhalation (6 ± 0.83 mg/m3). Proinflammatory biomarkers were measured in multiple tissues including arteries, brain, lung, and plasma. Biomarkers of cardiovascular injury were also assayed in plasma. CB inhalation exposure increased CMI-related proinflammatory biomarkers such as IFN-γ and TNFα in multiple tissue samples. CB exposure also induced cardiovascular injury markers (adiponectin, MCP1, sE-Selectin, sICam-1 and TIMP1) in plasma. These findings support the validity of our animal exposure model for studies of burn pit-induced CMI. Future studies will model more complex toxicant mixtures as documented at multiple burn pit sites.Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Incineration
/
Soot
Type of study:
Prognostic_studies
Limits:
Animals
Language:
En
Journal:
BMC Res Notes
Year:
2022
Document type:
Article
Affiliation country:
United States