Transcriptomic Analysis Reveals That Granulocyte Colony-Stimulating Factor Trigger a Novel Signaling Pathway (TAF9-P53-TRIAP1-CASP3) to Protect Retinal Ganglion Cells after Ischemic Optic Neuropathy.

Tsai, Rong-Kung; Lin, Keh-Liang; Huang, Chin-Te; Wen, Yao-Tseng

Tsai, Rong-Kung; Lin, Keh-Liang; Huang, Chin-Te; Wen, Yao-Tseng.

Affiliation

Tsai RK; Institute of Eye Research, Hualien Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation, Hualien 970473, Taiwan.
Lin KL; Institute of Medical Sciences, Tzu Chi University, Hualien 970374, Taiwan.
Huang CT; Doctoral Degree Program in Translational Medicine, Tzu Chi University and Academia Sinica, Hualien 970374, Taiwan.
Wen YT; Department of Optometry, Mackay Medical College, New Taipei City 252005, Taiwan.

Int J Mol Sci ; 23(15)2022 Jul 28.

Article in En | MEDLINE | ID: mdl-35955492

Subject(s)

Optic Neuropathy, Ischemic; Animals; Apoptosis/genetics; Caspase 3/metabolism; Disease Models, Animal; Granulocyte Colony-Stimulating Factor/metabolism; Granulocyte Colony-Stimulating Factor/pharmacology; Infarction; Optic Neuropathy, Ischemic/genetics; RNA, Small Interfering/metabolism; Rats; Rats, Wistar; Retinal Ganglion Cells/metabolism; Signal Transduction; Transcriptome; Tumor Suppressor Protein p53/genetics; Tumor Suppressor Protein p53/metabolism

Key words

TBP associated factor 9; TP53 regulated inhibitor of apoptosis 1; rat anterior ischemic optic neuropathy model; retinal ganglion cell death; transcriptome

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Optic Neuropathy, Ischemic Type of study: Prognostic_studies Limits: Animals Language: En Journal: Int J Mol Sci Year: 2022 Document type: Article Affiliation country: Taiwan Country of publication: Switzerland

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