Effect of statin on age-related hearing loss via drug repurposing.
Biochim Biophys Acta Mol Cell Res
; 1869(11): 119331, 2022 11.
Article
in En
| MEDLINE
| ID: mdl-35963547
ABSTRACT
Hearing loss in the elderly cause communication difficulties, decreased quality of life, isolation, loneliness and frustration. The aim of our study was to investigate the effect of drug repurposing candidates in aging mouse. The selected candidate drugs for age-related hearing loss (ARHL) included atorvastatin (AS) and sarpogrelate. Monotherapy or fixed dose combination (FDC) products were administered via oral gavage for 6 consecutive months. Auditory outcomes showed significant hearing preservation in AS-treated aging mice compared to aging control, especially in the early stages of ARHL in both 8 and 16 kHz frequencies. However, none of the FDC products were able to prevent ARHL regardless of AS involvement. In aging mice, damage and dysfunction of mitochondria was noted as well as reactive oxygen species overproduction leading to oxidative stress and intrinsic apoptosis. These processes of ARHL were significantly prevented with administration of AS. Normal structures of mitochondria were maintained, and antioxidant activity were proceeded by activation of HSF1/Sirt1 pathway. Our study suggests that AS is a promising drug repurposing candidate to delay the progression of ARHL.
Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Presbycusis
/
Hydroxymethylglutaryl-CoA Reductase Inhibitors
Aspects:
Patient_preference
Limits:
Animals
Language:
En
Journal:
Biochim Biophys Acta Mol Cell Res
Year:
2022
Document type:
Article