Loss of NKCC1 function increases epithelial tight junction permeability by upregulating claudin-2 expression.

Koumangoye, Rainelli; Penny, Parker; Delpire, Eric

Koumangoye, Rainelli; Penny, Parker; Delpire, Eric.

Affiliation

Koumangoye R; Department of Anesthesiology, Vanderbilt University School of Medicine, Nashville, Tennessee.
Penny P; Department of Anesthesiology, Vanderbilt University School of Medicine, Nashville, Tennessee.
Delpire E; Department of Anesthesiology, Vanderbilt University School of Medicine, Nashville, Tennessee.

Am J Physiol Cell Physiol ; 323(4): C1251-C1263, 2022 Oct 01.

Article in En | MEDLINE | ID: mdl-35968893

Subject(s)

Claudin-2; Tight Junctions; Cations/metabolism; Claudin-2/genetics; Claudin-2/metabolism; Dextrans/metabolism; Fluoresceins/metabolism; Humans; Inflammation/metabolism; Intestinal Mucosa/metabolism; Occludin/genetics; Occludin/metabolism; Permeability; Solute Carrier Family 12, Member 2/genetics; Solute Carrier Family 12, Member 2/metabolism; Tight Junction Proteins/metabolism; Tight Junctions/metabolism

Key words

HT29 cells; MDCK cells; NKCC1 knockout; intestinal barrier permeability; transepithelial electrical resistance

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Tight Junctions / Claudin-2 Limits: Humans Language: En Journal: Am J Physiol Cell Physiol Journal subject: FISIOLOGIA Year: 2022 Document type: Article Country of publication: United States

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