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All-in-one disulfide bridging enables the generation of antibody conjugates with modular cargo loading.
Dannheim, Friederike M; Walsh, Stephen J; Orozco, Carolina T; Hansen, Anders Højgaard; Bargh, Jonathan D; Jackson, Sophie E; Bond, Nicholas J; Parker, Jeremy S; Carroll, Jason S; Spring, David R.
Affiliation
  • Dannheim FM; Yusuf Hamied Department of Chemistry, University of Cambridge Cambridge CB2 1EW UK spring@ch.cam.ac.uk.
  • Walsh SJ; Yusuf Hamied Department of Chemistry, University of Cambridge Cambridge CB2 1EW UK spring@ch.cam.ac.uk.
  • Orozco CT; Cancer Research UK Cambridge Institute, University of Cambridge Cambridge CB2 0RE UK Jason.carroll@cruk.cam.ac.uk.
  • Hansen AH; Yusuf Hamied Department of Chemistry, University of Cambridge Cambridge CB2 1EW UK spring@ch.cam.ac.uk.
  • Bargh JD; Yusuf Hamied Department of Chemistry, University of Cambridge Cambridge CB2 1EW UK spring@ch.cam.ac.uk.
  • Jackson SE; Department of Chemistry, Technical University of Denmark (DTU) 2800 Kgs. Lyngby Denmark.
  • Bond NJ; Yusuf Hamied Department of Chemistry, University of Cambridge Cambridge CB2 1EW UK spring@ch.cam.ac.uk.
  • Parker JS; Yusuf Hamied Department of Chemistry, University of Cambridge Cambridge CB2 1EW UK spring@ch.cam.ac.uk.
  • Carroll JS; Analytical Sciences, Biopharmaceutical Development, R&D, AstraZeneca Granta Park Cambridge CB21 6GH UK.
  • Spring DR; Early Chemical Development, Pharmaceutical Development, R&D, AstraZeneca Macclesfield SK10 2NA UK.
Chem Sci ; 13(30): 8781-8790, 2022 Aug 04.
Article in En | MEDLINE | ID: mdl-35975158
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Full text: 1 Collection: 01-internacional Database: MEDLINE Language: En Journal: Chem Sci Year: 2022 Document type: Article Country of publication: United kingdom
Fulltext
Add to My VHL
Print
XML
PubMed Links
Search on Google

Full text: 1 Collection: 01-internacional Database: MEDLINE Language: En Journal: Chem Sci Year: 2022 Document type: Article Country of publication: United kingdom