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Single session versus multisession stereotactic radiosurgery for the management of intracranial meningiomas: a systematic review and meta-analysis.
Bin-Alamer, Othman; Alnefaie, Nada; Qedair, Jumanah; Chaudhary, Adhiraj; Hallak, Hana; Abdulbaki, Arif; Mallela, Arka N; Palmisciano, Paolo; Gersey, Zachary C; Legarreta, Andrew D; Labib, Mohamed A; Zada, Gabriel; Sheehan, Jason P; Couldwell, William T; Lunsford, L Dade; Abou-Al-Shaar, Hussam.
Affiliation
  • Bin-Alamer O; Department of Neurological Surgery, University of Pittsburgh Medical Center, Pittsburgh, PA, USA.
  • Alnefaie N; Department of Neurosurgery, National Neurosciences Institute, King Fahad Medical City, Riyadh, Saudi Arabia.
  • Qedair J; College of Medicine, King Saud bin Abdulaziz University for Health Sciences, Jeddah, Saudi Arabia.
  • Chaudhary A; Vardhman Mahavir Medical College and Safdarjung Hospital, New Delhi, India.
  • Hallak H; College of Medicine, Alfaisal University, Riyadh, Saudi Arabia.
  • Abdulbaki A; Department of Neurosurgery, Hannover Medical School, Hannover, Germany.
  • Mallela AN; Department of Neurological Surgery, University of Pittsburgh Medical Center, Pittsburgh, PA, USA.
  • Palmisciano P; Department of Neurosurgery, University of Cincinnati College of Medicine, Cincinnati, OH, USA.
  • Gersey ZC; Department of Neurological Surgery, University of Pittsburgh Medical Center, Pittsburgh, PA, USA.
  • Legarreta AD; Department of Neurological Surgery, University of Pittsburgh Medical Center, Pittsburgh, PA, USA.
  • Labib MA; Department of Neurosurgery, University of Maryland School of Medicine, Baltimore, MD, USA.
  • Zada G; Department of Neurosurgery, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.
  • Sheehan JP; Department of Neurosurgery, University of Virginia Health System, Charlottesville, VA, USA.
  • Couldwell WT; Department of Neurosurgery, Clinical Neurosciences Center, University of Utah, Salt Lake City, UT, USA.
  • Lunsford LD; Department of Neurological Surgery, University of Pittsburgh Medical Center, Pittsburgh, PA, USA.
  • Abou-Al-Shaar H; Department of Neurological Surgery, University of Pittsburgh Medical Center, Pittsburgh, PA, USA. aboualshaarh@upmc.edu.
J Neurooncol ; 161(2): 215-224, 2023 Jan.
Article in En | MEDLINE | ID: mdl-35976546
PURPOSE: To compare the efficacy, outcomes, and complications of single session (SS-SRS) and multisession (MS-SRS) stereotactic radiosurgery in the treatment of intracranial meningiomas. METHODS: Relevant articles were retrieved from PubMed, Scopus, Web of Science, and Cochrane. A systematic review and meta-analysis of treatment protocols and outcomes were conducted. After the selection process, 20 articles describing 1483 cases were included. RESULTS: A total of 1303 patients who underwent SS-SRS and 180 patients who underwent MS-SRS for the management of their intracranial meningioma were reported in the included studies. SS-SRS and MS-SRS had comparable one-year (SS-SRS: 98% vs. MS-SRS: 100%, p > 0.99) and five-year (SS-SRS: 94% vs. MS-SRS: 93%, p = 0.71) tumor control rates. The groups also had comparable tumor volume reduction/tumor regression rates (SS-SRS: 44% vs. MS-SRS: 25%, p = 0.25), tumor volume stability rates (SS-SRS: 51% vs. MS-SRS: 75%, p = 0.12), and tumor progression rates (SS-SRS: 4% vs. MS-SRS: 4%, p = 0.89). SS-SRS and MS-SRS yielded similar complication rates (10.4% vs. 11.4%, p = 0.68) and comparable functional improvement rates (MS-SRS: 44% vs. SS-SRS: 36%, p = 0.57). However, MS-SRS was used for significantly larger tumor volumes (MS-SRS: 23.8 cm3 vs. SS-SRS: 6.1 cm3, p = 0.02). CONCLUSION: SS-SRS and MS-SRS resulted in comparable tumor control, tumor volumetric change, and functional outcomes despite significant biases in selecting patients for SS- or MS-SRS.
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Radiosurgery / Meningeal Neoplasms / Meningioma Type of study: Guideline / Systematic_reviews Limits: Humans Language: En Journal: J Neurooncol Year: 2023 Document type: Article Affiliation country: United States Country of publication: United States
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Radiosurgery / Meningeal Neoplasms / Meningioma Type of study: Guideline / Systematic_reviews Limits: Humans Language: En Journal: J Neurooncol Year: 2023 Document type: Article Affiliation country: United States Country of publication: United States