A Methoxyflavanone from Perilla frutescens Induces Cellular Senescence in A549 Human Lung Adenocarcinoma Cells but Not in Normal Human Bronchial Epithelial Cells.
Biol Pharm Bull
; 45(10): 1581-1584, 2022 Oct 01.
Article
in En
| MEDLINE
| ID: mdl-35979561
ABSTRACT
Cellular senescence is an inherent tumor suppressive process, and cancer-targeted senescence induction represents an attractive anti-tumor strategy. Here, we show that a methoxyflavanone derivative (Perilla-derived methoxyflavanone, PDMF) from the Asian medicinal herb, Perilla frutescens, induces cellular senescence in A549 human adenocarcinoma cells but not in normal human bronchial epithelial (NHBE) cells. We also provide evidence that PDMF preferentially activates the p53-p21 pathway in A549 cells, and that p53 is essential for its pro-senescent activity.
Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Perilla frutescens
/
Adenocarcinoma of Lung
Limits:
Humans
Language:
En
Journal:
Biol Pharm Bull
Journal subject:
BIOQUIMICA
/
FARMACOLOGIA
Year:
2022
Document type:
Article