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Site-selective C-H alkylation of myo-inositol via organic photoredox catalysis.
Cao, Haonan; Guo, Tianyun; Deng, Xuemei; Huo, Xing; Tang, Shouchu; Liu, Jian; Wang, Xiaolei.
Affiliation
  • Cao H; School of Pharmacy, State Key Laboratory of Applied Organic Chemistry, Lanzhou University, Lanzhou 730000, P. R. China. jianliu@lzu.edu.cn.
  • Guo T; School of Pharmacy, State Key Laboratory of Applied Organic Chemistry, Lanzhou University, Lanzhou 730000, P. R. China. jianliu@lzu.edu.cn.
  • Deng X; School of Pharmacy, State Key Laboratory of Applied Organic Chemistry, Lanzhou University, Lanzhou 730000, P. R. China. jianliu@lzu.edu.cn.
  • Huo X; School of Pharmacy, State Key Laboratory of Applied Organic Chemistry, Lanzhou University, Lanzhou 730000, P. R. China. jianliu@lzu.edu.cn.
  • Tang S; School of Pharmacy, State Key Laboratory of Applied Organic Chemistry, Lanzhou University, Lanzhou 730000, P. R. China. jianliu@lzu.edu.cn.
  • Liu J; School of Pharmacy, State Key Laboratory of Applied Organic Chemistry, Lanzhou University, Lanzhou 730000, P. R. China. jianliu@lzu.edu.cn.
  • Wang X; School of Pharmacy, State Key Laboratory of Applied Organic Chemistry, Lanzhou University, Lanzhou 730000, P. R. China. jianliu@lzu.edu.cn.
Chem Commun (Camb) ; 58(71): 9934-9937, 2022 Sep 01.
Article in En | MEDLINE | ID: mdl-35983711
ABSTRACT
Site-selective photoredox reactions with aromatic olefins enable direct alkylation of unprotected myo-inositol at C4. The efficacy of these reactions can be finely tuned by modifying the structures of HAT reagents. These reactions open the possibility of selective C-H alkylations of myo-inositol without the need for multi-step protection-deprotection strategies.
Subject(s)

Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Alkenes / Inositol Language: En Journal: Chem Commun (Camb) Journal subject: QUIMICA Year: 2022 Document type: Article

Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Alkenes / Inositol Language: En Journal: Chem Commun (Camb) Journal subject: QUIMICA Year: 2022 Document type: Article