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Pharmacologic Inhibition of NT5C2 Reverses Genetic and Nongenetic Drivers of 6-MP Resistance in Acute Lymphoblastic Leukemia.
Reglero, Clara; Dieck, Chelsea L; Zask, Arie; Forouhar, Farhad; Laurent, Anouchka P; Lin, Wen-Hsuan W; Albero, Robert; Miller, Hannah I; Ma, Cindy; Gastier-Foster, Julie M; Loh, Mignon L; Tong, Liang; Stockwell, Brent R; Palomero, Teresa; Ferrando, Adolfo A.
Affiliation
  • Reglero C; Institute for Cancer Genetics, Columbia University, New York, New York.
  • Dieck CL; Institute for Cancer Genetics, Columbia University, New York, New York.
  • Zask A; Department of Biological Sciences and Department of Chemistry, Columbia University, New York, New York.
  • Forouhar F; Proteomics and Macromolecular Crystallography Shared Resource, Herbert Irving Comprehensive Cancer Center, Columbia University, New York, New York.
  • Laurent AP; Institute for Cancer Genetics, Columbia University, New York, New York.
  • Lin WW; Department of Pathology and Cell Biology, Columbia University Medical Center, New York, New York.
  • Albero R; Institute for Cancer Genetics, Columbia University, New York, New York.
  • Miller HI; Institute for Cancer Genetics, Columbia University, New York, New York.
  • Ma C; Institute for Cancer Genetics, Columbia University, New York, New York.
  • Gastier-Foster JM; Department of Pediatrics, Baylor College of Medicine, Houston, Texas.
  • Loh ML; Children's Oncology Group, Arcadia, California.
  • Tong L; Division of Hematology, Oncology, Bone Marrow Transplant, and Cellular Therapies, Seattle Children's Hospital, University of Washington, Seattle, Washington.
  • Stockwell BR; Department of Biological Sciences, Northeast Structural Genomics Consortium, Columbia University, New York, New York.
  • Palomero T; Department of Biological Sciences and Department of Chemistry, Columbia University, New York, New York.
  • Ferrando AA; Institute for Cancer Genetics, Columbia University, New York, New York.
Cancer Discov ; 12(11): 2646-2665, 2022 11 02.
Article in En | MEDLINE | ID: mdl-35984649
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Precursor Cell Lymphoblastic Leukemia-Lymphoma / Antineoplastic Agents Type of study: Guideline Limits: Humans Language: En Journal: Cancer Discov Year: 2022 Document type: Article Country of publication: United States
Fulltext
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Precursor Cell Lymphoblastic Leukemia-Lymphoma / Antineoplastic Agents Type of study: Guideline Limits: Humans Language: En Journal: Cancer Discov Year: 2022 Document type: Article Country of publication: United States