RPS6KA5 methylation predict response to 6-week treatment for adolescent MDD patients.
BMC Psychiatry
; 22(1): 561, 2022 08 19.
Article
in En
| MEDLINE
| ID: mdl-35986314
ABSTRACT
OBJECTIVE:
We aimed to investigate the effect of differentially methylated genes and chronic childhood stress on the development of depressive symptoms in Chinese adolescents, as well as to test whether methylation at baseline can be used as a predictor of remission at follow-up after six weeks of treatment.METHODS:
After recruiting 87 MDD patients and 53 healthy controls, we compared demographic and baseline clinical characteristics. The Childhood Chronic Stress Questionnaire was used to assess stress caused by early-life events. MDD patients underwent six weeks of treatment, and response to treatment was assessed using the Beck Depression Inventory-II. In addition, four MDD patients and five controls were randomly chosen for genome-wide methylation analysis.RESULTS:
The gene RPS6KA5 showed significant methylation differences between the two groups. Severity of chronic childhood stress was significantly associated with increased risk of depression in adolescents, but not with treatment response. Baseline RPS6KA5 methylation can predict remission after six weeks of treatment. We did not observe any interaction between RPS6KA5 methylation and chronic childhood stress.CONCLUSIONS:
Our results suggest that RPS6KA5 methylation can be used as a predictor of response to treatment in adolescent MDD patients. Here we offer new evidence for the role of epigenetics in early response to treatment of depression. TRIAL REGISTRATION ChiCTR, ChiCTR2000033402, 31/05/2020, http//www.chictr.org.cn/index.aspx.Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Depressive Disorder, Major
Type of study:
Prognostic_studies
/
Risk_factors_studies
Limits:
Adolescent
/
Child
/
Humans
Language:
En
Journal:
BMC Psychiatry
Journal subject:
PSIQUIATRIA
Year:
2022
Document type:
Article
Affiliation country:
China