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Extracellular stiffness induces contractile dysfunction in adult cardiomyocytes via cell-autonomous and microtubule-dependent mechanisms.
Vite, Alexia; Caporizzo, Matthew A; Corbin, Elise A; Brandimarto, Jeffrey; McAfee, Quentin; Livingston, Carissa E; Prosser, Benjamin L; Margulies, Kenneth B.
Affiliation
  • Vite A; Department of Medicine and Cardiovascular Institute, Perelman School of Medicine, University of Pennsylvania, 3400 Civic Center Boulevard, Smillow TRC 11-101, Philadelphia, PA, 19104, USA.
  • Caporizzo MA; Department of Molecular Physiology and Biophysics, University of Vermont's Larner College of Medicine, Burlington, VT, USA.
  • Corbin EA; Departments of Biomedical Engineering and Materials Science, University of Delaware, Newark, DE, USA.
  • Brandimarto J; Department of Medicine and Cardiovascular Institute, Perelman School of Medicine, University of Pennsylvania, 3400 Civic Center Boulevard, Smillow TRC 11-101, Philadelphia, PA, 19104, USA.
  • McAfee Q; Department of Medicine and Cardiovascular Institute, Perelman School of Medicine, University of Pennsylvania, 3400 Civic Center Boulevard, Smillow TRC 11-101, Philadelphia, PA, 19104, USA.
  • Livingston CE; Department of Medicine and Cardiovascular Institute, Perelman School of Medicine, University of Pennsylvania, 3400 Civic Center Boulevard, Smillow TRC 11-101, Philadelphia, PA, 19104, USA.
  • Prosser BL; Department of Physiology and Pennsylvania Muscle Institute, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
  • Margulies KB; Department of Medicine and Cardiovascular Institute, Perelman School of Medicine, University of Pennsylvania, 3400 Civic Center Boulevard, Smillow TRC 11-101, Philadelphia, PA, 19104, USA. kenb@pennmedicine.upenn.edu.
Basic Res Cardiol ; 117(1): 41, 2022 08 25.
Article in En | MEDLINE | ID: mdl-36006489
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Myocytes, Cardiac / Microtubules Limits: Animals Language: En Journal: Basic Res Cardiol Year: 2022 Document type: Article Affiliation country: United States Country of publication: Germany
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Myocytes, Cardiac / Microtubules Limits: Animals Language: En Journal: Basic Res Cardiol Year: 2022 Document type: Article Affiliation country: United States Country of publication: Germany