Therapeutic Effect of Melatonin in Premature Ovarian Insufficiency: Hippo Pathway Is Involved.
Oxid Med Cell Longev
; 2022: 3425877, 2022.
Article
in En
| MEDLINE
| ID: mdl-36017238
ABSTRACT
Objective:
Premature ovarian insufficiency (POI) is a female reproductive disorder of unknown etiology with no definite pathogenesis. Melatonin (MT) is an endogenous hormone synthesized mainly by pineal cells and has strong endogenous effects in regulating ovarian function. To systematically explore the pharmacological mechanism of MT on POI therapy, a literature review approach was conducted at the signaling pathways level.Methods:
Relevant literatures were searched and downloaded from databases, including PubMed and China National Knowledge Infrastructure, using the keywords "premature ovarian insufficiency," "Hippo signaling pathways," and "melatonin." The search criteria were from 2010 to 2022. Text mining was also performed.Results:
MT is involved in the regulation of Hippo signaling pathway in a variety of modes and has been correlated with ovarian function.Conclusions:
The purpose of this review is to summarize the research progress of Hippo signaling pathways and significance of MT in POI, the potential crosstalk between MT and Hippo signaling pathways, and the prospective therapy.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Primary Ovarian Insufficiency
/
Melatonin
Limits:
Female
/
Humans
Country/Region as subject:
Asia
Language:
En
Journal:
Oxid Med Cell Longev
Journal subject:
METABOLISMO
Year:
2022
Document type:
Article
Affiliation country:
China