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Discovery of CH7057288 as an Orally Bioavailable, Selective, and Potent pan-TRK Inhibitor.
Ito, Toshiya; Kinoshita, Kazutomo; Tomizawa, Masaki; Shinohara, Shojiro; Nishii, Hiroki; Matsushita, Masayuki; Hattori, Kazuo; Kohchi, Yasunori; Kohchi, Masami; Hayase, Tadakatsu; Watanabe, Fumio; Hasegawa, Kiyoshi; Tanaka, Hiroshi; Kuramoto, Shino; Takanashi, Kenji; Oikawa, Nobuhiro.
Affiliation
  • Ito T; Research Division, Chugai Pharmaceutical Co. Ltd., 1-135 Komakado, Gotemba, Shizuoka 412-8513, Japan.
  • Kinoshita K; Research Division, Chugai Pharmaceutical Co. Ltd., 1-135 Komakado, Gotemba, Shizuoka 412-8513, Japan.
  • Tomizawa M; Research Division, Chugai Pharmaceutical Co. Ltd., 1-135 Komakado, Gotemba, Shizuoka 412-8513, Japan.
  • Shinohara S; Research Division, Chugai Pharmaceutical Co. Ltd., 1-135 Komakado, Gotemba, Shizuoka 412-8513, Japan.
  • Nishii H; Research Division, Chugai Pharmaceutical Co. Ltd., 200 Kajiwara, Kamakura, Kanagawa 247-8530, Japan.
  • Matsushita M; Research Division, Chugai Pharmaceutical Co. Ltd., 200 Kajiwara, Kamakura, Kanagawa 247-8530, Japan.
  • Hattori K; Research Division, Chugai Pharmaceutical Co. Ltd., 200 Kajiwara, Kamakura, Kanagawa 247-8530, Japan.
  • Kohchi Y; Research Division, Chugai Pharmaceutical Co. Ltd., 200 Kajiwara, Kamakura, Kanagawa 247-8530, Japan.
  • Kohchi M; Research Division, Chugai Pharmaceutical Co. Ltd., 200 Kajiwara, Kamakura, Kanagawa 247-8530, Japan.
  • Hayase T; Research Division, Chugai Pharmaceutical Co. Ltd., 200 Kajiwara, Kamakura, Kanagawa 247-8530, Japan.
  • Watanabe F; Research Division, Chugai Pharmaceutical Co. Ltd., 200 Kajiwara, Kamakura, Kanagawa 247-8530, Japan.
  • Hasegawa K; Research Division, Chugai Pharmaceutical Co. Ltd., 200 Kajiwara, Kamakura, Kanagawa 247-8530, Japan.
  • Tanaka H; Research Division, Chugai Pharmaceutical Co. Ltd., 200 Kajiwara, Kamakura, Kanagawa 247-8530, Japan.
  • Kuramoto S; Research Division, Chugai Pharmaceutical Co. Ltd., 200 Kajiwara, Kamakura, Kanagawa 247-8530, Japan.
  • Takanashi K; Research Division, Chugai Pharmaceutical Co. Ltd., 1-135 Komakado, Gotemba, Shizuoka 412-8513, Japan.
  • Oikawa N; Research Division, Chugai Pharmaceutical Co. Ltd., 200 Kajiwara, Kamakura, Kanagawa 247-8530, Japan.
J Med Chem ; 65(18): 12427-12444, 2022 09 22.
Article in En | MEDLINE | ID: mdl-36066182
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Tropomyosin / Neoplasms Limits: Humans Language: En Journal: J Med Chem Journal subject: QUIMICA Year: 2022 Document type: Article Affiliation country: Japan Country of publication: United States
Fulltext
Add to My VHL
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Tropomyosin / Neoplasms Limits: Humans Language: En Journal: J Med Chem Journal subject: QUIMICA Year: 2022 Document type: Article Affiliation country: Japan Country of publication: United States