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Diversity oriented clicking delivers ß-substituted alkenyl sulfonyl fluorides as covalent human neutrophil elastase inhibitors.
Cheng, Yunfei; Li, Gencheng; Smedley, Christopher J; Giel, Marie-Claire; Kitamura, Seiya; Woehl, Jordan L; Bianco, Giulia; Forli, Stefano; Homer, Joshua A; Cappiello, John R; Wolan, Dennis W; Moses, John E; Sharpless, K Barry.
Affiliation
  • Cheng Y; Department of Chemistry, The Scripps Research Institute, La Jolla, CA 92037.
  • Li G; Department of Chemistry, The Scripps Research Institute, La Jolla, CA 92037.
  • Smedley CJ; La Trobe Institute for Molecular Science, Melbourne, VIC 3086, Australia.
  • Giel MC; La Trobe Institute for Molecular Science, Melbourne, VIC 3086, Australia.
  • Kitamura S; Department of Chemistry, The Scripps Research Institute, La Jolla, CA 92037.
  • Woehl JL; Department of Molecular Medicine, The Scripps Research Institute, La Jolla, CA 92037.
  • Bianco G; Department of Integrative Structural and Computational Biology, The Scripps Research Institute, La Jolla, CA 92037.
  • Forli S; Department of Molecular Medicine, The Scripps Research Institute, La Jolla, CA 92037.
  • Homer JA; Department of Integrative Structural and Computational Biology, The Scripps Research Institute, La Jolla, CA 92037.
  • Cappiello JR; Department of Integrative Structural and Computational Biology, The Scripps Research Institute, La Jolla, CA 92037.
  • Wolan DW; Cancer Center, Cold Spring Harbor Laboratory, Cold Spring Harbor, NY 11724.
  • Moses JE; Department of Chemistry, The Scripps Research Institute, La Jolla, CA 92037.
  • Sharpless KB; Department of Molecular Medicine, The Scripps Research Institute, La Jolla, CA 92037.
Proc Natl Acad Sci U S A ; 119(37): e2208540119, 2022 09 13.
Article in En | MEDLINE | ID: mdl-36070343
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Sulfinic Acids / Leukocyte Elastase / Proteinase Inhibitory Proteins, Secretory / Click Chemistry / Fluorides Limits: Humans Language: En Journal: Proc Natl Acad Sci U S A Year: 2022 Document type: Article Country of publication: United States
Fulltext
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Sulfinic Acids / Leukocyte Elastase / Proteinase Inhibitory Proteins, Secretory / Click Chemistry / Fluorides Limits: Humans Language: En Journal: Proc Natl Acad Sci U S A Year: 2022 Document type: Article Country of publication: United States