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Effect of remdesivir on mortality rate and clinical status of COVID-19 patients: a systematic review with meta-analysis.
Sellitto, Carmine; Corbi, Graziamaria; Bertini, Nicola; Ascione, Tiziana; Costantino, Maria; Scarpati, Giuliana; Piazza, Ornella; Filippelli, Amelia; Conti, Valeria; Pagliano, Pasquale.
Affiliation
  • Sellitto C; Unit of Pharmacology, Department of Medicine, Surgery and Dentistry, "Scuola Medica Salernitana", University of Salerno, Baronissi, Italy.
  • Corbi G; Department of Medicine and Health Sciences "V. Tiberio", University of Molise, Campobasso, Italy.
  • Bertini N; Unit of Pharmacology, Department of Medicine, Surgery and Dentistry, "Scuola Medica Salernitana", University of Salerno, Baronissi, Italy.
  • Ascione T; Department of Medicine, Service of Infectious Diseases, Cardarelli Hospital, Naples, Italy.
  • Costantino M; Unit of Pharmacology, Department of Medicine, Surgery and Dentistry, "Scuola Medica Salernitana", University of Salerno, Baronissi, Italy.
  • Scarpati G; Association Non-Profit F.I.R.S.Thermae (Interdisciplinary Training, Researches and Spa Sciences), Naples, Italy.
  • Piazza O; Unit of Anesthesiology, Department of Medicine, Surgery and Dentistry, "Scuola Medica Salernitana", University of Salerno, Baronissi, Italy.
  • Filippelli A; Unit of Anesthesiology, Department of Medicine, Surgery and Dentistry, "Scuola Medica Salernitana", University of Salerno, Baronissi, Italy.
  • Conti V; Unit of Pharmacology, Department of Medicine, Surgery and Dentistry, "Scuola Medica Salernitana", University of Salerno, Baronissi, Italy.
  • Pagliano P; Unit of Pharmacology, Department of Medicine, Surgery and Dentistry, "Scuola Medica Salernitana", University of Salerno, Baronissi, Italy.
J Chemother ; 35(5): 383-396, 2023 Sep.
Article in En | MEDLINE | ID: mdl-36102273
ABSTRACT
Remdesivir (RDV) is a broad-spectrum antiviral drug, now approved by Regulatory Agencies for COVID-19 treatment. RDV is associated with improvements in clinical outcomes, but no conclusive studies have shown an effect in reducing mortality. This study aimed to carry out a systematic review with meta-analysis to investigate whether RDV can significantly modify the outcome of COVID-19 patients evaluating its effects on mortality, length of stay, time to clinical improvement and need for oxygen supplementation. No significant improvement in terms of survival in patients treated with standard therapy (ST)+RDV as compared to ST alone (P = 0.24) was found. The duration of oxygen support was significantly lower in patients treated with ST + RDV compared with ST alone (P = 0.03). Further investigations should be planned to assess the real impact of RDV in the management of COVID-19 patients.
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: COVID-19 Type of study: Systematic_reviews Limits: Humans Language: En Journal: J Chemother Journal subject: ANTINEOPLASICOS / TERAPIA POR MEDICAMENTOS Year: 2023 Document type: Article Affiliation country: Italy
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: COVID-19 Type of study: Systematic_reviews Limits: Humans Language: En Journal: J Chemother Journal subject: ANTINEOPLASICOS / TERAPIA POR MEDICAMENTOS Year: 2023 Document type: Article Affiliation country: Italy