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Actinopolymorphols E and F, pyrazine alkaloids from a marine sediment-derived bacterium Streptomyces sp.
Kim, Sohee; Hillman, Prima F; Lee, Ji Young; Lee, Juri; Lee, Jihye; Cha, Sun-Shin; Oh, Dong-Chan; Nam, Sang-Jip; Fenical, William.
Affiliation
  • Kim S; The Graduate School of Industrial Pharmaceutical Sciences, College of Pharmacy, Ewha Womans University, Seoul, 03760, Republic of Korea.
  • Hillman PF; Laboratories of Marine New Drugs, REDONE SEOUL, Seoul, 08594, Republic of Korea.
  • Lee JY; Department of Chemistry and Nanoscience, Ewha Womans University, Seoul, 03760, Republic of Korea.
  • Lee J; Department of Chemistry and Nanoscience, Ewha Womans University, Seoul, 03760, Republic of Korea.
  • Lee J; Department of Chemistry and Nanoscience, Ewha Womans University, Seoul, 03760, Republic of Korea.
  • Cha SS; Laboratories of Marine New Drugs, REDONE SEOUL, Seoul, 08594, Republic of Korea.
  • Oh DC; Department of Chemistry and Nanoscience, Ewha Womans University, Seoul, 03760, Republic of Korea.
  • Nam SJ; Department of Chemistry and Nanoscience, Ewha Womans University, Seoul, 03760, Republic of Korea.
  • Fenical W; Natural Products Research Institute, College of Pharmacy, Seoul National University, Seoul, 08826, Republic of Korea.
J Antibiot (Tokyo) ; 75(11): 619-625, 2022 Nov.
Article in En | MEDLINE | ID: mdl-36109669
HPLC-UV-guided fractionation of crude extract from the marine sediment-derived bacterium Streptomyces sp. CNP-944 has yielded two new pyrazine alkaloids, actinopolymorphols E and F (1 and 2), in addition to the previously reported biosynthetic product, actinopolymorphol G (3), and the known actinopolymorphol D (4). The chemical structures of 1-3 were determined based on the interpretation of the 1D, 2D NMR, and MS spectroscopic data. Compound 2 displayed weak antibacterial activities against Kocuria rhizophila, Bacillus subtilis, and Staphylococcus aureus with minimum inhibitory concentration (MIC) values of 16, 64, and 64 µg ml-1, respectively.
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Streptomyces / Alkaloids Language: En Journal: J Antibiot (Tokyo) Year: 2022 Document type: Article Country of publication: United kingdom
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Streptomyces / Alkaloids Language: En Journal: J Antibiot (Tokyo) Year: 2022 Document type: Article Country of publication: United kingdom