Development and validation of a highly sensitive and selective LC-MS/MS method for the determination of 15-hydroxylubiprostone in human plasma: application to a pharmacokinetic study in healthy Chinese volunteers.

Li, Xianjing; Yu, Haitao; Guo, Wenjing; Cheng, Minlu; Song, Qinxin; Ding, Li

Li, Xianjing; Yu, Haitao; Guo, Wenjing; Cheng, Minlu; Song, Qinxin; Ding, Li.

Affiliation

Li X; Key Laboratory of Drug Quality Control and Pharmacovigilance, Ministry of Education, School of Pharmacy, China Pharmaceutical University, Nanjing, China.
Yu H; Department of Pharmaceutical Analysis, China Pharmaceutical University, Nanjing, China.
Guo W; Nanjing Chia Tai Tianqing Pharmaceutical Co., Ltd, Nanjing, China.
Cheng M; Key Laboratory of Drug Quality Control and Pharmacovigilance, Ministry of Education, School of Pharmacy, China Pharmaceutical University, Nanjing, China.
Song Q; Department of Pharmaceutical Analysis, China Pharmaceutical University, Nanjing, China.
Ding L; Nanjing Clinical Tech. Laboratories Inc, Nanjing, China.

Xenobiotica ; 52(6): 567-574, 2022 Jun.

Article in En | MEDLINE | ID: mdl-36129160

Subject(s)

Alprostadil; Tandem Mass Spectrometry; Capsules; China; Chromatography, Liquid/methods; Healthy Volunteers; Humans; Lubiprostone; Reproducibility of Results; Tandem Mass Spectrometry/methods

Key words

15-hydroxylubiprostone; LC-MS/MS; liquid-liquid extraction; pharmacokinetics; prostaglandin

Fulltext

Add to My VHL

XML

PubMed Links

Search on Google

Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Alprostadil / Tandem Mass Spectrometry Type of study: Diagnostic_studies / Guideline Limits: Humans Country/Region as subject: Asia Language: En Journal: Xenobiotica Year: 2022 Document type: Article Affiliation country: China

Fulltext

Add to My VHL

XML

PubMed Links

Search on Google