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Discovery of selective HDAC6 inhibitors capped by flavonoid or flavonoid-analogous moieties as anti-cancer therapeutics simultaneously harboring anti-proliferative and immunomodulatory activities.
He, Ge; Li, Zhi; Zhang, Mingming; Li, Zeng; Wang, Yujie; Zhao, Fang; Wang, Yang; Ma, Xiaodong.
Affiliation
  • He G; School of Pharmacy, Anhui University of Chinese Medicine, Hefei 230012, China.
  • Li Z; School of Pharmacy, Anhui University of Chinese Medicine, Hefei 230012, China.
  • Zhang M; School of Pharmacy, Anhui University of Chinese Medicine, Hefei 230012, China.
  • Li Z; The Key Laboratory of Major Autoimmune Diseases, Anhui Institute of Innovative Drugs, School of Pharmacy, Anhui Medical University, The Key Laboratory of Anti-inflammatory and Immune Medicines, Ministry of Education, Hefei 230032, China.
  • Wang Y; School of Pharmacy, Anhui University of Chinese Medicine, Hefei 230012, China.
  • Zhao F; School of Pharmacy, Anhui University of Chinese Medicine, Hefei 230012, China.
  • Wang Y; School of Pharmacy, Anhui University of Chinese Medicine, Hefei 230012, China; Department of Medicinal Chemistry, Anhui Academy of Chinese Medicine, Hefei 230012, China. Electronic address: wangyang1991@ahtcm.edu.cn.
  • Ma X; School of Pharmacy, Anhui University of Chinese Medicine, Hefei 230012, China; Department of Medicinal Chemistry, Anhui Academy of Chinese Medicine, Hefei 230012, China; Anhui Province Key Laboratory of Research & Development of Chinese Medicine, Hefei 230012, China. Electronic address: tgmx
Bioorg Chem ; 129: 106146, 2022 Dec.
Article in En | MEDLINE | ID: mdl-36130439
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Flavonoids / Histone Deacetylase Inhibitors Limits: Animals / Humans Language: En Journal: Bioorg Chem Year: 2022 Document type: Article Affiliation country: China
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Flavonoids / Histone Deacetylase Inhibitors Limits: Animals / Humans Language: En Journal: Bioorg Chem Year: 2022 Document type: Article Affiliation country: China