In Silico Studies Reveal Peramivir and Zanamivir as an Optimal Drug Treatment Even If H7N9 Avian Type Influenza Virus Acquires Further Resistance.

Sarukhanyan, Edita; Shanmugam, Tipack Ayothyapattanam; Dandekar, Thomas

Sarukhanyan, Edita; Shanmugam, Tipack Ayothyapattanam; Dandekar, Thomas.

Affiliation

Sarukhanyan E; Department of Bioinformatics, Biocenter, Am Hubland, University of Würzburg, 97074 Würzburg, Germany.
Shanmugam TA; Department of Bioinformatics, Biocenter, Am Hubland, University of Würzburg, 97074 Würzburg, Germany.
Dandekar T; Department of Bioinformatics, Biocenter, Am Hubland, University of Würzburg, 97074 Würzburg, Germany.

Molecules ; 27(18)2022 Sep 12.

Article in En | MEDLINE | ID: mdl-36144655

Subject(s)

Influenza A Virus, H7N9 Subtype; Influenza, Human; Acids, Carbocyclic; Antiviral Agents/chemistry; Arginine/pharmacology; Benserazide/pharmacology; Benserazide/therapeutic use; Drug Resistance, Viral/genetics; Enzyme Inhibitors/pharmacology; Guanidines/pharmacology; Guanidines/therapeutic use; Humans; Influenza A Virus, H7N9 Subtype/genetics; Influenza A Virus, H7N9 Subtype/metabolism; Influenza, Human/drug therapy; Molecular Docking Simulation; Mutation; Neuraminidase/chemistry; Oseltamivir/pharmacology; Zanamivir/pharmacology

Key words

H7N9 influenza virus; binding pocket; molecular docking; mutation; neuraminidase

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Influenza, Human / Influenza A Virus, H7N9 Subtype Limits: Humans Language: En Journal: Molecules Journal subject: BIOLOGIA Year: 2022 Document type: Article Affiliation country: Germany Country of publication: Switzerland

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