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Treatment with cefiderocol in K. pneumoniae KPC nosocomial external ventricular drainage meningitis: A brief report.
Colombo, Francesco; Waheed, Ali; Panese, Sandro; Scarparo, Claudio; Solinas, Maria; Parisi, Saverio Giuseppe; Geremia, Nicholas.
Affiliation
  • Colombo F; Department of Molecular Medicine, University of Padova, Padua, Italy.
  • Waheed A; Department of Molecular Medicine, University of Padova, Padua, Italy.
  • Panese S; Unit of Infectious Diseases, Department of Clinical Medicine, Ospedale dell'Angelo, Venice, Italy.
  • Scarparo C; Unit of Microbiology and Virology, Ospedale dell'Angelo, Department of Medical Direction, Ospedale "dell'Angelo", Venice, Italy.
  • Solinas M; Unit of Microbiology and Virology, Ospedale dell'Angelo, Department of Medical Direction, Ospedale "dell'Angelo", Venice, Italy.
  • Parisi SG; Department of Molecular Medicine, University of Padova, Padua, Italy.
  • Geremia N; Unit of Infectious Diseases, Department of Clinical Medicine, Ospedale dell'Angelo, Venice, Italy.
Infez Med ; 30(3): 454-458, 2022.
Article in En | MEDLINE | ID: mdl-36148162
ABSTRACT
We report the case of successful use of cefiderocol (FDC) in a Carbapenemase Producing K. pneumoniae (CPKP) post-surgical meningitis in a 44-year-old man treated with antimicrobial therapy and external ventricular drainage (EVD). The patient was known for being colonised by CPKP; for this reason, therapy with ceftazidime/avibactam (CZA) plus fosfomycin and linezolid was started. After an initial response a CZA resistant CPKP strain was isolated from CSF culture, so the antibiotic therapy was modified to FDC with trimethoprim/sulfamethoxazole for 14 days, and EVD was replaced. A complete recovery was obtained. This is the first case report describing FDC administration in CPKP meningitis.
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Full text: 1 Collection: 01-internacional Database: MEDLINE Language: En Journal: Infez Med Journal subject: ALERGIA E IMUNOLOGIA Year: 2022 Document type: Article Affiliation country: Italy
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Full text: 1 Collection: 01-internacional Database: MEDLINE Language: En Journal: Infez Med Journal subject: ALERGIA E IMUNOLOGIA Year: 2022 Document type: Article Affiliation country: Italy