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What a difference a methylene makes: replacing Glu with Asp or Aad in the Lys-urea-Glu pharmacophore of PSMA-targeting radioligands to reduce kidney and salivary gland uptake.
Kuo, Hsiou-Ting; Lin, Kuo-Shyan; Zhang, Zhengxing; Zhang, Chengcheng; Merkens, Helen; Tan, Ruiyan; Roxin, Aron; Uribe, Carlos F; Bénard, François.
Affiliation
  • Kuo HT; Department of Molecular Oncology, BC Cancer, Vancouver, BC V5Z1L3, Canada.
  • Lin KS; Department of Molecular Oncology, BC Cancer, Vancouver, BC V5Z1L3, Canada.
  • Zhang Z; Department of Functional Imaging, BC Cancer, Vancouver, BC V5Z4E6, Canada.
  • Zhang C; Department of Radiology, University of British Columbia, Vancouver, BC V5Z1M9, Canada.
  • Merkens H; Department of Molecular Oncology, BC Cancer, Vancouver, BC V5Z1L3, Canada.
  • Tan R; Department of Molecular Oncology, BC Cancer, Vancouver, BC V5Z1L3, Canada.
  • Roxin A; Department of Molecular Oncology, BC Cancer, Vancouver, BC V5Z1L3, Canada.
  • Uribe CF; Department of Molecular Oncology, BC Cancer, Vancouver, BC V5Z1L3, Canada.
  • Bénard F; Department of Molecular Oncology, BC Cancer, Vancouver, BC V5Z1L3, Canada.
Theranostics ; 12(14): 6179-6188, 2022.
Article in En | MEDLINE | ID: mdl-36168623
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Prostatic Neoplasms / Glutamate Carboxypeptidase II Limits: Animals / Humans / Male Language: En Journal: Theranostics Year: 2022 Document type: Article Affiliation country: Canada
Fulltext
Add to My VHL
Print
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PubMed Links
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Prostatic Neoplasms / Glutamate Carboxypeptidase II Limits: Animals / Humans / Male Language: En Journal: Theranostics Year: 2022 Document type: Article Affiliation country: Canada