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A G358S mutation in the Plasmodium falciparum Na+ pump PfATP4 confers clinically-relevant resistance to cipargamin.
Qiu, Deyun; Pei, Jinxin V; Rosling, James E O; Thathy, Vandana; Li, Dongdi; Xue, Yi; Tanner, John D; Penington, Jocelyn Sietsma; Aw, Yi Tong Vincent; Aw, Jessica Yi Han; Xu, Guoyue; Tripathi, Abhai K; Gnadig, Nina F; Yeo, Tomas; Fairhurst, Kate J; Stokes, Barbara H; Murithi, James M; Kümpornsin, Krittikorn; Hasemer, Heath; Dennis, Adelaide S M; Ridgway, Melanie C; Schmitt, Esther K; Straimer, Judith; Papenfuss, Anthony T; Lee, Marcus C S; Corry, Ben; Sinnis, Photini; Fidock, David A; van Dooren, Giel G; Kirk, Kiaran; Lehane, Adele M.
Affiliation
  • Qiu D; Research School of Biology, Australian National University, Canberra, ACT, 2600, Australia.
  • Pei JV; Research School of Biology, Australian National University, Canberra, ACT, 2600, Australia.
  • Rosling JEO; Research School of Biology, Australian National University, Canberra, ACT, 2600, Australia.
  • Thathy V; Department of Microbiology & Immunology, Columbia University Irving Medical Center, New York, NY, 10032, USA.
  • Li D; Research School of Biology, Australian National University, Canberra, ACT, 2600, Australia.
  • Xue Y; Research School of Biology, Australian National University, Canberra, ACT, 2600, Australia.
  • Tanner JD; Research School of Biology, Australian National University, Canberra, ACT, 2600, Australia.
  • Penington JS; Bioinformatic Division, The Walter & Eliza Hall Institute of Medical Research, Parkville, VIC, 3052, Australia.
  • Aw YTV; Research School of Biology, Australian National University, Canberra, ACT, 2600, Australia.
  • Aw JYH; Research School of Biology, Australian National University, Canberra, ACT, 2600, Australia.
  • Xu G; Department of Molecular Microbiology & Immunology and Johns Hopkins Malaria Institute, Johns Hopkins School of Public Health, Baltimore, MD, 21205, USA.
  • Tripathi AK; Department of Molecular Microbiology & Immunology and Johns Hopkins Malaria Institute, Johns Hopkins School of Public Health, Baltimore, MD, 21205, USA.
  • Gnadig NF; Department of Microbiology & Immunology, Columbia University Irving Medical Center, New York, NY, 10032, USA.
  • Yeo T; Department of Microbiology & Immunology, Columbia University Irving Medical Center, New York, NY, 10032, USA.
  • Fairhurst KJ; Department of Microbiology & Immunology, Columbia University Irving Medical Center, New York, NY, 10032, USA.
  • Stokes BH; Department of Microbiology & Immunology, Columbia University Irving Medical Center, New York, NY, 10032, USA.
  • Murithi JM; Department of Microbiology & Immunology, Columbia University Irving Medical Center, New York, NY, 10032, USA.
  • Kümpornsin K; Wellcome Sanger Institute, Wellcome Genome Campus, Hinxton, CB10 1SA, UK.
  • Hasemer H; Research School of Biology, Australian National University, Canberra, ACT, 2600, Australia.
  • Dennis ASM; Research School of Biology, Australian National University, Canberra, ACT, 2600, Australia.
  • Ridgway MC; Research School of Biology, Australian National University, Canberra, ACT, 2600, Australia.
  • Schmitt EK; Novartis Pharma AG, Novartis Campus, Basel, 4056, Switzerland.
  • Straimer J; Novartis Institute for Tropical Diseases, Emeryville, CA, 94608, USA.
  • Papenfuss AT; Bioinformatic Division, The Walter & Eliza Hall Institute of Medical Research, Parkville, VIC, 3052, Australia.
  • Lee MCS; Department of Medical Biology, The University of Melbourne, Parkville, VIC, 3052, Australia.
  • Corry B; Wellcome Sanger Institute, Wellcome Genome Campus, Hinxton, CB10 1SA, UK.
  • Sinnis P; Research School of Biology, Australian National University, Canberra, ACT, 2600, Australia.
  • Fidock DA; Department of Molecular Microbiology & Immunology and Johns Hopkins Malaria Institute, Johns Hopkins School of Public Health, Baltimore, MD, 21205, USA.
  • van Dooren GG; Department of Microbiology & Immunology, Columbia University Irving Medical Center, New York, NY, 10032, USA.
  • Kirk K; Center for Malaria Therapeutics and Antimicrobial Resistance, Division of Infectious Diseases, Department of Medicine, Columbia University Irving Medical Center, New York, NY, 10032, USA.
  • Lehane AM; Research School of Biology, Australian National University, Canberra, ACT, 2600, Australia.
Nat Commun ; 13(1): 5746, 2022 09 30.
Article in En | MEDLINE | ID: mdl-36180431
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Malaria, Falciparum / Antimalarials Limits: Humans Language: En Journal: Nat Commun Journal subject: BIOLOGIA / CIENCIA Year: 2022 Document type: Article Affiliation country: Australia
Fulltext
Add to My VHL
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Malaria, Falciparum / Antimalarials Limits: Humans Language: En Journal: Nat Commun Journal subject: BIOLOGIA / CIENCIA Year: 2022 Document type: Article Affiliation country: Australia