Androgen receptor activity in prostate cancer dictates efficacy of bipolar androgen therapy through MYC.

Sena, Laura A; Kumar, Rajendra; Sanin, David E; Thompson, Elizabeth A; Rosen, D Marc; Dalrymple, Susan L; Antony, Lizamma; Yang, Yuhan; Gomes-Alexandre, Carolina; Hicks, Jessica L; Jones, Tracy; Bowers, Kiara A; Eskra, Jillian N; Meyers, Jennifer; Gupta, Anuj; Skaist, Alyza; Yegnasubramanian, Srinivasan; Luo, Jun; Brennen, W Nathaniel; Kachhap, Sushant K; Antonarakis, Emmanuel S; De Marzo, Angelo M; Isaacs, John T; Markowski, Mark C; Denmeade, Samuel R

Sena, Laura A; Kumar, Rajendra; Sanin, David E; Thompson, Elizabeth A; Rosen, D Marc; Dalrymple, Susan L; Antony, Lizamma; Yang, Yuhan; Gomes-Alexandre, Carolina; Hicks, Jessica L; Jones, Tracy; Bowers, Kiara A; Eskra, Jillian N; Meyers, Jennifer; Gupta, Anuj; Skaist, Alyza; Yegnasubramanian, Srinivasan; Luo, Jun; Brennen, W Nathaniel; Kachhap, Sushant K; Antonarakis, Emmanuel S; De Marzo, Angelo M; Isaacs, John T; Markowski, Mark C; Denmeade, Samuel R.

J Clin Invest ; 132(23)2022 12 01.

Article in En | MEDLINE | ID: mdl-36194476

Subject(s)

Prostatic Neoplasms, Castration-Resistant; Receptors, Androgen; Male; Humans; Receptors, Androgen/metabolism; Androgens/pharmacology; Prostatic Neoplasms, Castration-Resistant/metabolism; Androgen Receptor Antagonists/pharmacology; Androgen Receptor Antagonists/therapeutic use; Nitriles; Testosterone/pharmacology; Drug Resistance, Neoplasm; Cell Line, Tumor

Key words

Oncology; Prostate cancer

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Receptors, Androgen / Prostatic Neoplasms, Castration-Resistant Type of study: Prognostic_studies Limits: Humans / Male Language: En Journal: J Clin Invest Year: 2022 Document type: Article

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