Bioprosthetic Total Artificial Heart Implantation Does Not Induce Chronic Inflammation.
ASAIO J
; 68(11): e173-e178, 2022 11 01.
Article
in En
| MEDLINE
| ID: mdl-36228635
ABSTRACT
The Aeson total artificial heart (A-TAH) has been developed for patients at risk of death from biventricular failure. We aimed to assess the inflammatory status in nine subjects implanted with the A-TAH in kinetics over one year. Laboratory assessment of leukocyte counts, inflammatory cytokines assay, and peripheral blood mononuclear cell collection before and after A-TAH implantation. Leukocyte counts were not significantly modulated according to time after A-TAH implantation (coefficient of the linear mixed effect model with 95% CI, -0.05 (-0.71 to -0.61); p = 0.44). We explored inflammatory cytokine after A-TAH and did not observe, at any time, a modified profile compared to pre-implantation values (all p -values > 0.05). Finally, we compared the distribution of circulating immune cell subpopulations identified based on sequential expression patterns for multiple clusters of differentiation. None of the population explored had significant modulation during the 12-month follow-up (all p -values > 0.05). In conclusion, using a cytokine multiplex assay combined with a flow cytometry approach, we demonstrated the absence of inflammatory signals in peripheral blood over a period of 12 months following A-TAH implantation.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Heart Transplantation
/
Heart, Artificial
/
Heart Failure
Type of study:
Etiology_studies
Limits:
Humans
Language:
En
Journal:
ASAIO J
Journal subject:
TRANSPLANTE
Year:
2022
Document type:
Article
Affiliation country:
France